CRL2KLHDC3 mediates p14ARF N-terminal ubiquitylation degradation to promote non-small cell lung carcinoma progression

• Published in: Oncogene Vol. 41; no. 22; pp. 3104 - 3117
• Main Authors: Liu, Yang, Luo, Yuewen, Yan, Shumei, Lian, Yi-Fan, Wu, Shiyu, Xu, Miao, Feng, Lin, Zhang, Xu, Li, Rong, Zhang, Xiantao, Feng, Qi-Sheng, Zeng, Yi-Xin, Zhang, Hui
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 27.05.2022; Nature Publishing Group
• Subjects: 13/105; 13/109; 13/51; 13/89; 38/1; 38/77; 631/67/1612/1350; 631/80/458/582; 64/60; 692/53; 82/29; 82/58; 82/80; Adaptor proteins; Apoptosis; Carcinogenesis; Cell Biology; Degradation; Drug development; Drug resistance; Epidermal growth factor; Epidermal growth factor receptors; Gefitinib; Human Genetics; Internal Medicine; Kelch protein; Lung cancer; Lung carcinoma; Medicine; Medicine & Public Health; Non-small cell lung carcinoma; Oncology; Small cell lung carcinoma; Targeted cancer therapy; Tumor suppressor genes; Tumors; Ubiquitin; Ubiquitin-protein ligase

Kelch superfamily involves a variety of proteins containing multiple kelch motif and is well characterized as substrate adaptors for CUL3 E3 ligases, which play critical roles in carcinogenesis. However, the role of kelch proteins in lung cancer remains largely unknown. In this study, the non-small...