Characterization of neuronal spiking patterns in the medial prefrontal cortex under varied general anesthetics in mice

• Published in: ANESTHESIOLOGY AND PERIOPERATIVE SCIENCE Vol. 3; no. 1; pp. 1 - 17
• Main Authors: Hu, Xiangyu, Jiang, Jingyao, Leng, Yu, Yang, Yaoxin, Zhang, Donghang, Li, Ke, Zhu, Tao, Liang, Peng, Zhou, Cheng
• Format: Journal Article
• Language: English
• Published: Singapore Springer Nature Singapore 25.02.2025; Springer
• Subjects: Anesthesiology; Animal model; Critical Care Medicine; General anesthetics; Intensive; Loss of righting reflex; Medicine; Medicine & Public Health; mPFC; Neuronal spiking; Neurosciences; Original Research; Pharmacology/Toxicology; Surgery; Neuronal spiking; Animal model; mPFC; General anesthetics; Loss of righting reflex

Purpose The mechanisms underlying reversible unconsciousness induced by general anesthetics remain unclear. This study aimed to investigate the effects of four commonly used anesthetics on neuronal spiking patterns in layer 5 of the medial prefrontal cortex (mPFC). Methods In vivo multi-channel reco...