On the search for new anticancer drugs 14: the plasma pharmacokinetics and tissue distribution of spin-labeled thio-TEPA (SL-O-TT)

• Published in: Cancer chemotherapy and pharmacology Vol. 15; no. 3; p. 185
• Main Authors: Gutierrez, P L, Cohen, B E, Sosnovsky, G, Davis, T A, Egorin, M J
• Format: Journal Article
• Language: English
• Published: Germany 01.01.1985
• Subjects: Animals; Chromatography, Gas; Electron Spin Resonance Spectroscopy; Half-Life; Kinetics; Male; Mice; Spin Labels - metabolism; Thiotepa - analogs & derivatives; Thiotepa - blood; Thiotepa - metabolism; Tissue Distribution

We defined the plasma and tissue concentrations and pharmacokinetics of SL-O-TT, a spin-labeled analog of thio-TEPA, in 35-44-g male Swiss Webster mice that had received spin-labeled thio-TEPA at a dosage of 10 mg/kg. Concentrations of spin-labeled thio-TEPA in ethyl acetate extracts of tissue and p...