Degradation products of the promethazine radical cation

The degradation products of the promethazine radical cation, generated from promethazine with horseradish peroxidase/H2O2, have been investigated. Several products have been identified which resulted from fission of the bond between the two ethanamine carbon atoms of the N10 side chain. The main pro...

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Bibliographic Details
Published inPharmaceutisch weekblad. Scientific edition Vol. 7; no. 3; p. 121
Main Authors De Mol, N J, Koenen, J
Format Journal Article
LanguageEnglish
Published Netherlands 21.06.1985
Subjects
Cations
Chromatography, High Pressure Liquid
Free Radicals
Horseradish Peroxidase
Hydrogen Peroxide
Magnetic Resonance Spectroscopy
Mass Spectrometry
Promethazine - analysis
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Summary:The degradation products of the promethazine radical cation, generated from promethazine with horseradish peroxidase/H2O2, have been investigated. Several products have been identified which resulted from fission of the bond between the two ethanamine carbon atoms of the N10 side chain. The main product (approx. 90%) was identified as 10-formyl-5-oxophenothiazine. The likely structure of three minor products was also elucidated. The degradation of the promethazine radical cation is different from that of radical cations derived from the propanamine side chain containing phenothiazine drugs.
ISSN:0167-6555
DOI:10.1007/BF01968714