The capsaicin receptor TRPV1 reduces sepsis-associated brain injury in mice by inhibiting pyroptosis

• Published in: ANESTHESIOLOGY AND PERIOPERATIVE SCIENCE Vol. 3; no. 3; pp. 1 - 13
• Main Authors: Long, Menghong, Hu, Zhenyu, Long, Feiyu, Chen, Yingxu, Liu, Li, Wang, Maohua
• Format: Journal Article
• Language: English
• Published: Singapore Springer Nature Singapore 14.07.2025; Springer
• Subjects: Anesthesiology; Capsaicin; Critical Care Medicine; Intensive; Medicine; Medicine & Public Health; Neuroprotection; Neurosciences; NF-κB; Original Research; Pharmacology/Toxicology; Pyroptosis; Septic encephalopathy; Surgery; TRPV1; NF-κB; Neuroprotection; Pyroptosis; TRPV1; Septic encephalopathy; Capsaicin

Purpose Sepsis is a life-threatening disorder marked by organ dysfunction due to infection. Transient receptor potential vanilloid 1 (TRPV1) is a non-selective, ligand-gated cation channel activated by multiple stimuli. This study investigates the role of TRPV1 in sepsis-associated encephalopathy (S...