Role of Matrix Metalloproteinases in Models of Macrophage-Dependent Acute Lung Injury . Evidence for Alveolar Macrophage as Source of Proteinases

• Published in: American journal of respiratory cell and molecular biology Vol. 20; no. 6; pp. 1145 - 1154
• Main Authors: Gibbs, Douglas F, Shanley, Thomas P, Warner, Roscoe L, Murphy, Hedwig S, Varani, James, Johnson, Kent J
• Format: Journal Article
• Language: English
• Published: United States Am Thoracic Soc 01.06.1999
• Subjects: Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Extracellular Matrix - physiology; Humans; Immunoglobulin A - immunology; Lung - anatomy & histology; Macrophages, Alveolar - physiology; Male; Metalloendopeptidases - physiology; Neutrophils - physiology; Rats; Rats, Long-Evans; Respiratory Distress Syndrome, Adult - etiology; Tissue Inhibitor of Metalloproteinase-2 - pharmacology

Matrix metalloproteinases (MMPs) have been implicated in the tissue injury seen in neutrophil-dependent models of acute lung injury. However, the role of MMPs in macrophage-dependent models of lung injury is unknown. To address this issue, the macrophage-dependent immunoglobulin A immune complex-ind...