Toxicological profiling of a de novo synthesized benzimidazole derivative with potent and selective proapoptotic potentials against breast cancer

• Published in: Food and chemical toxicology Vol. 180; p. 114049
• Main Authors: Farrag, Ebtehal K., Aziz, Wessam M., Shaker, Sylvia E., Shawky, Heba, Fayed, Dalia B.
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.10.2023
• Subjects: Antioxidant; Apoptosis; Benzimidazole; Breast cancer; Cytotoxicity; G0/G1 phase arrest; Cytotoxicity; G0/G1 phase arrest; Breast cancer; Antioxidant; Benzimidazole; Apoptosis

This study aimed to investigate the toxicological profile of 1-(6-(1H-benzo[d]imidazole-2-yl)-2-methylpyridin-3-yl) ethanone (BMPE), both in vitro and in vivo. The proapoptotic/necrotic and cell cycle arrest potentials of BMPE were assessed in MCF-7 cell line. The in vivo toxicology was assessed in...