A WDR47 homolog facilitates ciliogenesis by modulating intraflagellar transport

• Published in: Journal of cell science Vol. 135; no. 24
• Main Authors: Song, Chun-Xue, Zeng, Xian-Ting, Zeng, Wan-Xin, Liu, Rong, Tong, Xia-Jing, Li, Qian
• Format: Journal Article
• Language: English
• Published: England 15.12.2022
• Subjects: Animals; Biological Transport; Caenorhabditis elegans; Cilia - metabolism; Ciliopathies - metabolism; Mammals; Neurons - metabolism; Chemosensory neuron; Intraflagellar transport; WD40-repeat protein; Cilia

Cilia are conserved organelles found in many cell types in eukaryotes, and their dysfunction causes defects in environmental sensing and signaling transduction; such defects are termed ciliopathies. Distinct cilia have cell-specific morphologies and exert distinct functions. However, the underlying...