Immunometabolic rewiring of tubular epithelial cells in kidney disease

• Published in: Nature reviews. Nephrology Vol. 18; no. 9; pp. 588 - 603
• Main Authors: van der Rijt, Sanne, Leemans, Jaklien C, Florquin, Sandrine, Houtkooper, Riekelt H, Tammaro, Alessandra
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group 01.09.2022
• Subjects: Energy; Fatty acids; Glucose; Immune system; Kidney diseases; Lipids; Metabolism; Metabolites; Oxidation; Pattern recognition; Phosphorylation

Kidney tubular epithelial cells (TECs) have a crucial role in the damage and repair response to acute and chronic injury. To adequately respond to constant changes in the environment, TECs have considerable bioenergetic needs, which are supported by metabolic pathways. Although little is known about...