The comparative cardiovascular effects of digoxin and food alone and in combination in normal males
The effects of the ingestion of food and digoxin on the cardiovascular system alone and in combination have been observed in eight healthy subjects. A positive inotropic response was seen following food (2.5 MJ) and intravenous digoxin (0.01 mg/kg) with significant decreases in QS2Index (QS2I) pre-e...
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Published in | European journal of clinical pharmacology Vol. 29; no. 6; p. 685 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
Germany
01.01.1986
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Subjects | |
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Abstract | The effects of the ingestion of food and digoxin on the cardiovascular system alone and in combination have been observed in eight healthy subjects. A positive inotropic response was seen following food (2.5 MJ) and intravenous digoxin (0.01 mg/kg) with significant decreases in QS2Index (QS2I) pre-ejection period (PEP) and PEP/LVET (LVET - left ventricular ejection time). These responses were potentiated when food and digoxin were combined. Opposing effects of food and digoxin on % diastole (%D) and diastolic time were observed, food decreasing %D and DT while digoxin increased these variables. Both food and digoxin decreased T-wave amplitude, and digoxin alone or in combination with food decreased QTc. The positive inotropic effect of a 2.5 MJ mixed meal and a loading dose of digoxin in healthy subjects are of similar degree, different mechanism, and are potentiated in combination. |
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AbstractList | The effects of the ingestion of food and digoxin on the cardiovascular system alone and in combination have been observed in eight healthy subjects. A positive inotropic response was seen following food (2.5 MJ) and intravenous digoxin (0.01 mg/kg) with significant decreases in QS2Index (QS2I) pre-ejection period (PEP) and PEP/LVET (LVET - left ventricular ejection time). These responses were potentiated when food and digoxin were combined. Opposing effects of food and digoxin on % diastole (%D) and diastolic time were observed, food decreasing %D and DT while digoxin increased these variables. Both food and digoxin decreased T-wave amplitude, and digoxin alone or in combination with food decreased QTc. The positive inotropic effect of a 2.5 MJ mixed meal and a loading dose of digoxin in healthy subjects are of similar degree, different mechanism, and are potentiated in combination. |
Author | Burgess, C D Crane, J |
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CitedBy_id | crossref_primary_10_1111_j_1939_1676_1992_tb03152_x crossref_primary_10_1016_j_etap_2020_103400 crossref_primary_10_1007_BF00637672 crossref_primary_10_1111_j_1540_8159_1999_tb06819_x |
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SubjectTerms | Adult Blood Pressure - drug effects Digoxin - pharmacology Electrocardiography Food Heart Rate - drug effects Hemodynamics - drug effects Humans Male |
Title | The comparative cardiovascular effects of digoxin and food alone and in combination in normal males |
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