LncRNA PRBC induces autophagy to promote breast cancer progression through modulating PABPC1-mediated mRNA stabilization

• Published in: Oncogene Vol. 43; no. 14; pp. 1019 - 1032
• Main Authors: Liang, Yiran, Chen, Bing, Xu, Fanchao, Long, Li, Ye, Fangzhou, Wang, Yajie, Luo, Dan, Li, Yaming, Zhao, Wenjing, Wang, Lijuan, Jin, Yuhan, Wang, Lei, Kong, Xiaoli, Su, Peng, Yang, Qifeng
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 28.03.2024
• Subjects: Argonaute 2 protein; Autophagy; Autophagy - genetics; Breast cancer; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Cell Line, Tumor; Cell Proliferation; Cytoplasm; Female; Gene Expression Regulation, Neoplastic; Humans; MicroRNAs - genetics; Molecular modelling; mRNA; Non-coding RNA; Poly(A)-Binding Protein I - genetics; Poly(A)-Binding Protein I - metabolism; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; RNA, Messenger - genetics; RNA-Binding Proteins - genetics; RNA-induced silencing complex; RNA-mediated interference; Therapeutic targets

Breast cancer is one of the major malignant tumors among women worldwide. Long noncoding RNAs (lncRNAs) have been documented as significant modulators in the development and progression of various cancers; however, the contribution of lncRNAs to breast cancer remains largely unknown. In this study,...