In Vivo Formation of Adrenal Organoids in a Novel Porcine Model of Adrenocortical Cell Transplantation

• Published in: Endocrinology (Philadelphia) Vol. 165; no. 8
• Main Authors: Clarke, Brigette Marie, Kireta, Svjetlana, Johnston, Julie, Christou, Chris, Greenwood, John Edward, Hurtado, Plinio R, Manavis, Jim, Coates, Patrick Toby, Torpy, David J
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 01.07.2024
• Subjects: Addison's disease; Adrenal Cortex - cytology; Adrenal Cortex - metabolism; Adrenal Glands - metabolism; Adrenalectomy; Adrenocorticotropic hormone; Animal models; Animals; Biodegradability; Biodegradation; Cell culture; Cell proliferation; Cell Transplantation - methods; Cellular manufacture; Corticoids; Corticosteroids; Female; Histochemistry; Hydrocortisone; Hydrocortisone - blood; In vivo methods and tests; Islet cells; Models, Animal; Organoids; Pancreas transplantation; Pancreatic islet transplantation; Steroids; Swine; Transplantation; Transplants & implants; adrenal; corticosteroids; animal model; Addison's disease; transplantation

Abstract Recognizing the limitations of current therapies for Addison's disease, novel treatments that replicate dynamic physiologic corticosteroid secretion, under control of ACTH, are required. The aim of these experiments was to evaluate the feasibility of adrenocortical cell transplantation...