Advanced cancer perineural invasion induces profound peripheral neuronal plasticity, pain, and somatosensory mechanical deactivation, unmitigated by the lack of TNFR1. Part. 1: Behavior and single-cell in vivo electrophysiology

• Published in: Molecular pain Vol. 21; p. 17448069251314738
• Main Authors: Gutierrez, Silvia, Parker, Renee A, Zhang, Morgan, Santi, Maria Daniela, Ye, Yi, Boada, M Danilo
• Format: Journal Article
• Language: English
• Published: United States SAGE Publications 01.01.2025
• Subjects: Animals; Behavior, Animal; Female; Ganglia, Spinal - metabolism; Ganglia, Spinal - pathology; Ganglia, Spinal - physiopathology; Hyperalgesia - pathology; Hyperalgesia - physiopathology; Male; Mice; Mice, Inbred C57BL; Neoplasm Invasiveness; Neuronal Plasticity - physiology; Pain - pathology; Pain - physiopathology; Receptors, Tumor Necrosis Factor, Type I - deficiency; Receptors, Tumor Necrosis Factor, Type I - metabolism; Sciatic Nerve - pathology; Sciatic Nerve - physiopathology; nociception; pain; PNI; somatosensory system; MOC2; Cancer

Patients with cancer perineural invasion (PNI) report greater spontaneous pain and mechanical allodynia. Here, we examine the impact of the disease on the peripheral sensory system, the excitability changes induced by PNI at the dorsal root ganglia, and the potential protective role of the absence o...