Insulin-like growth factor mediated stromal-epithelial interactions in human breast cancer

• Published in: Breast cancer research and treatment Vol. 31; no. 2-3; p. 249
• Main Authors: Ellis, M J, Singer, C, Hornby, A, Rasmussen, A, Cullen, K J
• Format: Journal Article
• Language: English
• Published: Netherlands 1994
• Subjects: Breast Neoplasms - genetics; Breast Neoplasms - pathology; Connective Tissue - metabolism; Connective Tissue - pathology; Disease Progression; Epithelium - pathology; Fibroblasts - metabolism; Fibroblasts - pathology; Gene Expression Regulation, Neoplastic; Growth Substances - biosynthesis; Growth Substances - physiology; Humans; Insulin-Like Growth Factor I - biosynthesis; Insulin-Like Growth Factor I - genetics; Insulin-Like Growth Factor I - physiology; Insulin-Like Growth Factor II - biosynthesis; Insulin-Like Growth Factor II - genetics; Insulin-Like Growth Factor II - pharmacology; Insulin-Like Growth Factor II - physiology; Neoplasm Proteins - biosynthesis; Neoplasm Proteins - genetics; Neoplasm Proteins - physiology; Neoplasms - genetics; Neoplasms - metabolism; Organ Specificity; Receptors, Somatomedin - genetics; Receptors, Somatomedin - physiology; Tumor Cells, Cultured

The prominent 'desmoplastic' or stromal reaction seen in many invasive breast carcinomas lead to early speculation that stromal cells play a role in breast cancer pathogenesis. Experimental evidence now supports this hypothesis and interactions between stromal cells and epithelial cells ap...