Astragalus Polysaccharides Reduce High-glucose-induced Rat Aortic Endothelial Cell Senescence and Inflammasome Activation by Modulating the Mitochondrial Na+/Ca2+ Exchanger

• Published in: Cell biochemistry and biophysics Vol. 80; no. 2; pp. 341 - 353
• Main Authors: Miao, Xin-Yu, Zhu, Xiao-Xiao, Gu, Zhao-Yan, Fu, Bo, Cui, Shao-Yuan, Zu, Yuan, Rong, Ling-Jun, Hu, Fan, Chen, Xiang-Mei, Gong, Yan-Ping, Li, Chun-Lin
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.06.2022; Springer Nature B.V
• Subjects: Aorta; Arteriosclerosis; Atherosclerosis; Autophagy; Biochemistry; Biological and Medical Physics; Biomedical and Life Sciences; Biophysics; Biotechnology; Calcium (mitochondrial); Calcium ions; Cardiovascular diseases; Cell activation; Cell Biology; Cytochrome-c oxidase; Cytochromes; Endothelial cells; Glucose; Herbal medicine; IL-1β; Inflammasomes; Life Sciences; Mitochondria; Na+/Ca2+ exchanger; Older people; Original Paper; Oxygen consumption; p53 Protein; Pharmacology/Toxicology; Polysaccharides; Proteins; Saccharides; Senescence; siRNA; Traditional Chinese medicine; Transfection; Vacuoles; Aging; Aorta; polysaccharide; NCLX; Endothelium

Vascular endothelial cells play a vital role in atherosclerotic changes and the progression of cardiovascular disease in older adults. Previous studies have indicated that Astragalus polysaccharides (APS), a main active component of the traditional Chinese medicine Astragalus , protect mitochondria...