LncRNA UCA1 promotes SOX12 expression in breast cancer by regulating m6A modification of miR-375 by METTL14 through DNA methylation

• Published in: Cancer gene therapy Vol. 29; no. 7; pp. 1043 - 1055
• Main Authors: Zhao, Chengpeng, Ling, Xiaoling, Xia, Yunxia, Yan, Bingxue, Guan, Quanlin
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.07.2022; Nature Publishing Group
• Subjects: 13/109; 13/51; 692/699/67; 692/699/67/1347; Apoptosis; Bioinformatics; Biomedical and Life Sciences; Biomedicine; Breast cancer; Cell proliferation; Cholecystokinin; DNA methylation; DNA methyltransferase; Flow cytometry; Gene Expression; Gene Therapy; Morbidity; N6-methyladenosine; Non-coding RNA; Risk factors; Tumors; Xenografts

Breast cancer, a multifactorial disease, represents one of the leading causes of cancer-related morbidity and mortality in women. This study set out to elucidate the underlying mechanism by which lncRNA UCA1 affects the m 6 A modification of miR-375 by mediating the DNA methylation of METTL14 and th...