Absorption enhancement of rectally infused insulin by sodium tauro-24,25-dihydrofusidate (STDHF) in rats

The bile salt derivative sodium tauro-24,25-dihydrofusidate (STDHF) has been reported to promote nasal absorption of insulin. In the present study the effect of STDHF on rectal insulin absorption was investigated in rats. At concentrations of 1 and 4% (w/v) it enhanced insulin bioavailability from 0...

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Bibliographic Details
Published inPharmaceutical research Vol. 7; no. 2; p. 180
Main Authors van Hoogdalem, E J, Heijligers-Feijen, C D, Verhoef, J C, de Boer, A G, Breimer, D D
Format Journal Article
LanguageEnglish
Published United States 01.02.1990
Subjects
Administration, Rectal
Animals
Biological Availability
Blood Glucose - metabolism
Edetic Acid - pharmacology
Fusidic Acid - analogs & derivatives
Fusidic Acid - pharmacology
Infusions, Intravenous
Insulin - administration & dosage
Insulin - blood
Insulin - pharmacokinetics
Intestinal Absorption - drug effects
Male
Rats
Rats, Inbred Strains
Stimulation, Chemical
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Summary:The bile salt derivative sodium tauro-24,25-dihydrofusidate (STDHF) has been reported to promote nasal absorption of insulin. In the present study the effect of STDHF on rectal insulin absorption was investigated in rats. At concentrations of 1 and 4% (w/v) it enhanced insulin bioavailability from 0.2 +/- 0.2 (control) to 4.2 +/- 3.2 and 6.7 +/- 2.1%, respectively, as assessed by radioimmunoassay. Insulin preparations with STDHF reduced blood glucose concentrations considerably in a concentration-dependent way. Coadministration of STDHF with Na2EDTA (0.25%, w/v) tended to increase further insulin bioavailability and hypoglycemic response. Varying the site of rectal administration did not influence these parameters.
ISSN:0724-8741
DOI:10.1023/A:1015837004307