Analysis of proinflammatory activity of highly purified eukaryotic recombinant HMGB1 (amphoterin)

• Published in: Journal of leukocyte biology Vol. 81; no. 1; pp. 49 - 58
• Main Authors: Rouhiainen, Ari, Tumova, Sarka, Valmu, Leena, Kalkkinen, Nisse, Rauvala, Heikki
• Format: Journal Article
• Language: English
• Published: Society for Leukocyte Biology 01.01.2007
• Subjects: inflammation; nitric oxide; phosphatidylserine; RAGE; TNF‐α

HMGB1 (amphoterin) is a 30‐kDa heparin‐binding protein that mediates transendothelial migration of monocytes and has proinflammatory cytokine‐like activities. In this study, we have investigated proinflammatory activities of both highly purified eukaryotic HMGB1 and bacterially produced recombinant...