Real-World Risk of Gastrointestinal Bleeding for Direct Oral Anticoagulants and Warfarin Users: A Distributed Network Analysis Using a Common Data Model

• Published in: Gut and liver Vol. 18; no. 5; pp. 814 - 823
• Main Authors: Cha, Jae Myung, Kim, Myoungsuk, Jo, Hyeong Ho, Seo, Won-Woo, Rhee, Sang Youl, Kim, Ji Hyun, Kim, Gwang Ha, Park, Junseok
• Format: Journal Article
• Language: English
• Published: Korea (South) Editorial Office of Gut and Liver 15.09.2024; Gastroenterology Council for Gut and Liver; 거트앤리버 소화기연관학회협의회
• Subjects: Administration, Oral; Aged; Aged, 80 and over; anticoagulants; Anticoagulants - adverse effects; cohort studies; common data model; Dabigatran - adverse effects; Factor Xa Inhibitors - adverse effects; Female; gastrointestinal hemorrhage; Gastrointestinal Hemorrhage - chemically induced; Gastrointestinal Hemorrhage - epidemiology; Humans; Male; Middle Aged; Original; Propensity Score; Pyrazoles - adverse effects; Pyridines - adverse effects; Pyridones - administration & dosage; Pyridones - adverse effects; Risk Assessment; Risk Factors; Rivaroxaban - adverse effects; Thiazoles - adverse effects; Warfarin - adverse effects; 내과학; Anticoagulants; Common data model; Cohort studies; Gastrointestinal hemorrhage

Early studies on direct oral anticoagulants (DOACs) reported a higher risk of gastrointestinal bleeding (GIB) compared with warfarin; however, recent studies have reported a reduced risk. Therefore, this study was designed to evaluate the risk of GIB in users of DOAC and warfarin. Using a common dat...