Benzo[a]pyrene promotes an epithelial‐to‐mesenchymal transition process in MCF10A cells and mammary tumor growth and brain metastasis in female mice
Breast cancer is the most frequent neoplasia in developed countries and the leading cause of death in women worldwide. Epithelial‐to‐mesenchymal transition (EMT) is a cellular process through which epithelial cells decrease or lose their epithelial characteristics and gain mesenchymal properties. EM...
Saved in:
Published in | Molecular carcinogenesis Vol. 63; no. 7; pp. 1319 - 1333 |
---|---|
Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
01.07.2024
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Breast cancer is the most frequent neoplasia in developed countries and the leading cause of death in women worldwide. Epithelial‐to‐mesenchymal transition (EMT) is a cellular process through which epithelial cells decrease or lose their epithelial characteristics and gain mesenchymal properties. EMT mediates tumor progression, because tumor cells acquire the capacity to execute the multiple steps of invasion and metastasis. Benzo[a]pyrene (B[a]P) is an environmental organic pollutant generated during the burning of fossil fuels, wood, and other organic materials. B[a]P exposition increases the incidence of breast cancer, and induces migration and/or invasion in MDA‐MB‐231 and MCF‐7 breast cancer cells. However, the role of B[a]P in the induction of an EMT process and metastasis of mammary carcinoma cells has not been studied in detail. In this study, we demonstrate that B[a]P induces an EMT process in MCF10A mammary non‐tumorigenic epithelial cells. In addition, B[a]P promotes the formation of larger tumors in Balb/cJ mice inoculated with 4T1 cells than in untreated mice and treated with dimethyl sulfoxide (DMSO). B[a]P also increases the number of mice with metastasis to brain and the total number of brain metastatic nodules in Balb/cJ mice inoculated with 4T1 cells compared with untreated mice and treated with DMSO. In conclusion, B[a]P induces an EMT process in MCF10A cells and the growth of mammary tumors and metastasis to brain in Balb/cJ mice inoculated with 4T1 cells. |
---|---|
AbstractList | Breast cancer is the most frequent neoplasia in developed countries and the leading cause of death in women worldwide. Epithelial-to-mesenchymal transition (EMT) is a cellular process through which epithelial cells decrease or lose their epithelial characteristics and gain mesenchymal properties. EMT mediates tumor progression, because tumor cells acquire the capacity to execute the multiple steps of invasion and metastasis. Benzo[a]pyrene (B[a]P) is an environmental organic pollutant generated during the burning of fossil fuels, wood, and other organic materials. B[a]P exposition increases the incidence of breast cancer, and induces migration and/or invasion in MDA-MB-231 and MCF-7 breast cancer cells. However, the role of B[a]P in the induction of an EMT process and metastasis of mammary carcinoma cells has not been studied in detail. In this study, we demonstrate that B[a]P induces an EMT process in MCF10A mammary non-tumorigenic epithelial cells. In addition, B[a]P promotes the formation of larger tumors in Balb/cJ mice inoculated with 4T1 cells than in untreated mice and treated with dimethyl sulfoxide (DMSO). B[a]P also increases the number of mice with metastasis to brain and the total number of brain metastatic nodules in Balb/cJ mice inoculated with 4T1 cells compared with untreated mice and treated with DMSO. In conclusion, B[a]P induces an EMT process in MCF10A cells and the growth of mammary tumors and metastasis to brain in Balb/cJ mice inoculated with 4T1 cells. Abstract Breast cancer is the most frequent neoplasia in developed countries and the leading cause of death in women worldwide. Epithelial‐to‐mesenchymal transition (EMT) is a cellular process through which epithelial cells decrease or lose their epithelial characteristics and gain mesenchymal properties. EMT mediates tumor progression, because tumor cells acquire the capacity to execute the multiple steps of invasion and metastasis. Benzo[ a ]pyrene (B[a]P) is an environmental organic pollutant generated during the burning of fossil fuels, wood, and other organic materials. B[a]P exposition increases the incidence of breast cancer, and induces migration and/or invasion in MDA‐MB‐231 and MCF‐7 breast cancer cells. However, the role of B[a]P in the induction of an EMT process and metastasis of mammary carcinoma cells has not been studied in detail. In this study, we demonstrate that B[a]P induces an EMT process in MCF10A mammary non‐tumorigenic epithelial cells. In addition, B[a]P promotes the formation of larger tumors in Balb/cJ mice inoculated with 4T1 cells than in untreated mice and treated with dimethyl sulfoxide (DMSO). B[a]P also increases the number of mice with metastasis to brain and the total number of brain metastatic nodules in Balb/cJ mice inoculated with 4T1 cells compared with untreated mice and treated with DMSO. In conclusion, B[a]P induces an EMT process in MCF10A cells and the growth of mammary tumors and metastasis to brain in Balb/cJ mice inoculated with 4T1 cells. |
Author | Garcia‐Hernandez, Alejandra Salazar, Eduardo Perez Candanedo‐Gonzales, Fernando Cortes‐Reynosa, Pedro Castillo‐Sanchez, Rocio Torres‐Alamilla, Pablo |
Author_xml | – sequence: 1 givenname: Rocio surname: Castillo‐Sanchez fullname: Castillo‐Sanchez, Rocio organization: Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional – sequence: 2 givenname: Alejandra surname: Garcia‐Hernandez fullname: Garcia‐Hernandez, Alejandra organization: Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional – sequence: 3 givenname: Pablo surname: Torres‐Alamilla fullname: Torres‐Alamilla, Pablo organization: Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional – sequence: 4 givenname: Pedro surname: Cortes‐Reynosa fullname: Cortes‐Reynosa, Pedro organization: Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional – sequence: 5 givenname: Fernando surname: Candanedo‐Gonzales fullname: Candanedo‐Gonzales, Fernando organization: Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran – sequence: 6 givenname: Eduardo Perez orcidid: 0000-0002-3041-7902 surname: Salazar fullname: Salazar, Eduardo Perez email: eduardo.perez@cinvestav.mx organization: Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/38629425$$D View this record in MEDLINE/PubMed |
BookMark | eNp1kc9O3DAQh62Kqiy0Ek9Q-cglYDuJkxxhxT8J1Et7qqpo4oy7RrG9tb1aLac-Qo88H09CsgvlhGTZh_nm0_w8B2TPeYeEHHF2whkTp1adiLwS8gOZcdbUmaiKYo_MWN00GW_qap8cxHjPGOdVyT6R_byWoilEOSOP5-ge_E_4tdwEdEiXwVufMFJwFJcmLXAwMDz9_Zf8eFmM6NRiY2GgKYCLJhnvpiaFMVLj6N38krMzqnAYJkdPLVgLYUPTyvpAfwe_TottoQsw8hYTxPGYbbfG0YzUGoWfyUcNQ8QvL-8h-XF58X1-nd1-u7qZn91mStRCZiBZ3omi6nUpOS96waXWXMqq01D0TOuaj2Cv8hpAdSWiLAssG-igKnXHmvyQHO-8Y4g_K4yptSZO44NDv4ptzgqWC8FZ9Yaq4GMMqNtlMFO4lrN22kNrVbvdw4h-fbGuOov9f_D140cg2wFrM-DmXVF7N98JnwG7RJfA |
Cites_doi | 10.1002/ijc.33588 10.1016/j.envint.2021.106399 10.1371/journal.pone.0098624 10.1038/nrm1699 10.18632/oncotarget.7953 10.1038/sj.onc.1206059 10.1186/s12943-016-0576-5 10.1016/j.toxlet.2018.05.005 10.1007/s10565-013-9254-1 10.1007/s00204-018-2291-z 10.1007/s10911-010-9177-x 10.1093/annonc/mds195 10.4103/2347-5625.189813 10.1016/j.ctrv.2011.11.001 10.1080/10406638.2018.1534747 10.1016/j.addr.2010.11.001 10.1007/s11864-019-0682-x 10.1080/01480545.2020.1774602 10.1016/j.toxlet.2015.02.016 10.1016/j.chemosphere.2017.06.017 10.1002/jat.3728 10.1200/JCO.2000.18.5.1135 10.1177/0960327117735572 10.1016/j.devcel.2019.04.010 10.1186/s13058-019-1116-1 10.1016/j.chemosphere.2006.12.011 10.1093/carcin/19.7.1291 10.1038/s41572-019-0111-2 10.4137/BCBCR.S25460 10.1387/ijdb.041794hp 10.1186/s12885-021-07860-2 10.1016/j.ceb.2005.08.014 10.1038/laban.254 10.3390/cancers12092342 10.3390/ijms23126806 10.1016/j.matbio.2005.07.004 10.1016/j.mce.2023.111998 10.1016/j.ceb.2005.08.007 10.1016/j.molmed.2008.03.004 10.1016/j.cell.2009.11.007 10.1002/jcb.21695 10.1038/nrc1075 10.1002/emmm.200900043 10.1101/pdb.prot073411 10.1038/ncb1094 10.3892/or.2017.5874 10.1093/carcin/21.7.1281 10.1016/S0278-6915(00)00158-7 10.1038/35000025 10.1083/jcb.148.4.779 10.1093/carcin/bgm122 10.1172/JCI200421358 10.3390/ijms23116348 10.1016/j.ceb.2003.10.006 10.3390/biom10020179 10.1093/carcin/18.6.1177 10.1016/j.bbrc.2009.04.051 10.1016/j.semcancer.2004.06.010 10.1038/nrc865 10.1016/bs.pmbts.2017.02.005 |
ContentType | Journal Article |
Copyright | 2024 The Authors. published by Wiley Periodicals LLC 2024 The Authors. Molecular Carcinogenesis published by Wiley Periodicals LLC. |
Copyright_xml | – notice: 2024 The Authors. published by Wiley Periodicals LLC – notice: 2024 The Authors. Molecular Carcinogenesis published by Wiley Periodicals LLC. |
DBID | 24P WIN CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 |
DOI | 10.1002/mc.23726 |
DatabaseName | Open Access: Wiley-Blackwell Open Access Journals Wiley Online Library Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic |
DatabaseTitleList | MEDLINE CrossRef MEDLINE - Academic |
Database_xml | – sequence: 1 dbid: 24P name: Open Access: Wiley-Blackwell Open Access Journals url: https://authorservices.wiley.com/open-science/open-access/browse-journals.html sourceTypes: Publisher – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine Biology |
EISSN | 1098-2744 |
EndPage | 1333 |
ExternalDocumentID | 10_1002_mc_23726 38629425 MC23726 |
Genre | researchArticle Journal Article |
GrantInformation_xml | – fundername: Consejo Nacional de Humanidades Ciencias y Tecnologías (CONAHCYT) funderid: 776512 – fundername: Consejo Nacional de Humanidades Ciencias y Tecnologías (CONAHCYT) grantid: 776512 |
GroupedDBID | --- .3N .GA .GJ .Y3 05W 0R~ 10A 123 1L6 1OB 1OC 1ZS 24P 31~ 33P 3SF 3WU 4.4 50Y 50Z 51W 51X 52M 52N 52O 52P 52R 52S 52T 52U 52V 52W 52X 53G 5VS 66C 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM 930 A01 A03 AAESR AAEVG AAHHS AANLZ AAONW AASGY AAXRX AAZKR ABCQN ABCUV ABEFU ABEML ABIJN ABJNI ABPVW ABQWH ABXGK ACAHQ ACBWZ ACCFJ ACCZN ACGFO ACGFS ACGOF ACMXC ACPOU ACPRK ACSCC ACXBN ACXQS ADBBV ADBTR ADEOM ADIZJ ADKYN ADMGS ADOZA ADXAS ADZMN AEEZP AEGXH AEIGN AEIMD AENEX AEQDE AEUQT AEUYR AFBPY AFFPM AFGKR AFPWT AFRAH AFZJQ AHBTC AIACR AIAGR AITYG AIURR AIWBW AJBDE ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN AMBMR AMYDB ASPBG ATUGU AVWKF AZBYB AZFZN AZVAB BAFTC BDRZF BFHJK BHBCM BMXJE BROTX BRXPI BY8 C45 CS3 D-6 D-7 D-E D-F DCZOG DPXWK DR2 DRFUL DRMAN DRSTM DU5 EBD EBS EJD EMOBN F00 F01 F04 F5P FEDTE FUBAC G-S G.N GLUZI GNP GODZA H.X HBH HF~ HGLYW HHY HHZ HVGLF HZ~ IH2 IX1 J0M JPC KBYEO KQQ LATKE LAW LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LYRES M6P MEWTI MK4 MRFUL MRMAN MRSTM MSFUL MSMAN MSSTM MXFUL MXMAN MXSTM N04 N05 N9A NF~ NNB O66 O9- OIG OVD P2P P2W P2X P2Z P4B P4D PALCI PQQKQ Q.N Q11 QB0 QRW R.K RIWAO RJQFR ROL RWI RX1 RYL SAMSI SUPJJ SV3 TEORI TUS UB1 V2E V8K W8V W99 WBKPD WHWMO WIB WIH WIJ WIK WIN WJL WOHZO WQJ WRC WUP WVDHM WWO WXI WXSBR XG1 XPP XV2 ZGI ZXP ZZTAW ~IA ~WT CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 |
ID | FETCH-LOGICAL-c2826-a603b247df56114d216ff1667bfa4d0ff81c28dc38aacb5ee654e59aba75fb093 |
IEDL.DBID | 24P |
ISSN | 0899-1987 |
IngestDate | Sat Aug 17 04:58:53 EDT 2024 Fri Aug 23 01:58:37 EDT 2024 Wed Oct 02 05:18:55 EDT 2024 Sat Aug 24 00:58:11 EDT 2024 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 7 |
Keywords | mammary tumors breast cancer metastasis EMT B[a]P |
Language | English |
License | Attribution-NonCommercial 2024 The Authors. Molecular Carcinogenesis published by Wiley Periodicals LLC. |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c2826-a603b247df56114d216ff1667bfa4d0ff81c28dc38aacb5ee654e59aba75fb093 |
Notes | Rocio Castillo‐Sanchez and Alejandra Garcia‐Hernandez contributed equally to this study. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ORCID | 0000-0002-3041-7902 |
OpenAccessLink | https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fmc.23726 |
PMID | 38629425 |
PQID | 3040322107 |
PQPubID | 23479 |
PageCount | 15 |
ParticipantIDs | proquest_miscellaneous_3040322107 crossref_primary_10_1002_mc_23726 pubmed_primary_38629425 wiley_primary_10_1002_mc_23726_MC23726 |
PublicationCentury | 2000 |
PublicationDate | July 2024 |
PublicationDateYYYYMMDD | 2024-07-01 |
PublicationDate_xml | – month: 07 year: 2024 text: July 2024 |
PublicationDecade | 2020 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States |
PublicationTitle | Molecular carcinogenesis |
PublicationTitleAlternate | Mol Carcinog |
PublicationYear | 2024 |
References | 2013; 29 2021; 21 2010; 15 2022; 23 2003; 15 2004; 6 2007; 70 2000; 2 2020; 12 2008; 104 2020; 10 2005; 24 2007; 28 2000; 18 1998; 19 2018; 294 2019; 20 2019; 21 2017; 38 2023; 575 2003; 3 2011; 63 1997; 18 2014; 9 2012; 23 2007; 67 2018; 37 2019; 5 2020; 40 2000; 21 2021; 149 2004; 48 2013; 42 2008; 14 2019; 39 2022; 45 2002; 2 2014; 2014 2012; 38 2015; 9 2009; 139 2016; 7 2004; 114 2016; 3 2000; 148 2017; 16 2015; 234 2004; 14 2018; 92 2019; 49 2005; 6 2017; 184 2001; 39 2009; 384 2014; 72 2005; 17 2009; 1 2003; 63 2017; 147 2003; 22 Baranwal S (e_1_2_10_15_1) 2009; 384 Chambers AF (e_1_2_10_21_1) 2002; 2 Malik D (e_1_2_10_30_1) 2018; 92 Santonicola S (e_1_2_10_60_1) 2017; 184 Chen X (e_1_2_10_50_1) 2017; 38 Jiang H (e_1_2_10_56_1) 2021; 21 Webb DJ (e_1_2_10_44_1) 2004; 6 Gao M (e_1_2_10_48_1) 2022; 45 Torres‐Alamilla P (e_1_2_10_36_1) 2023; 575 Xu X (e_1_2_10_41_1) 2016; 7 Guo J (e_1_2_10_47_1) 2015; 234 Nelson AR (e_1_2_10_54_1) 2000; 18 Shadboorestan A (e_1_2_10_32_1) 2019; 39 Amadou A (e_1_2_10_26_1) 2021; 149 Lee BM (e_1_2_10_28_1) 2007; 70 Barnwal P (e_1_2_10_58_1) 2018; 37 Cano A (e_1_2_10_16_1) 2000; 2 Cowin P (e_1_2_10_45_1) 2005; 17 Friedl P (e_1_2_10_20_1) 2003; 3 André F (e_1_2_10_8_1) 2012; 23 Brisson L (e_1_2_10_38_1) 2020; 12 López‐Novoa JM (e_1_2_10_34_1) 2009; 1 Kazerouni N (e_1_2_10_61_1) 2001; 39 Tapial Martínez P (e_1_2_10_43_1) 2020; 10 Albuquerque RC (e_1_2_10_5_1) 2014; 72 Bukowska B (e_1_2_10_27_1) 2022; 23 Gavert N (e_1_2_10_12_1) 2008; 14 Bailey‐Downs LC (e_1_2_10_37_1) 2014; 9 Gilles C (e_1_2_10_51_1) 2003; 63 Park M (e_1_2_10_9_1) 2022; 23 Gumbiner BM (e_1_2_10_18_1) 2005; 6 Peinado H (e_1_2_10_17_1) 2004; 48 Lu W (e_1_2_10_14_1) 2019; 49 Radisky ES (e_1_2_10_53_1) 2010; 15 Foroni C (e_1_2_10_19_1) 2012; 38 Thiery JP (e_1_2_10_10_1) 2009; 139 Zanieri L (e_1_2_10_49_1) 2007; 67 Kamalabadi M (e_1_2_10_59_1) 2020; 40 Castillo‐Sanchez R (e_1_2_10_31_1) 2013; 29 Li H (e_1_2_10_13_1) 2017; 16 Balansky R (e_1_2_10_29_1) 2007; 28 Tannheimer S (e_1_2_10_62_1) 1997; 18 Thiery JP (e_1_2_10_11_1) 2003; 15 Yang H (e_1_2_10_64_1) 2018; 294 Jin X (e_1_2_10_6_1) 2015; 9 Avizienyte E (e_1_2_10_22_1) 2005; 17 Cardiff RD (e_1_2_10_42_1) 2014; 2014 Zhao X (e_1_2_10_23_1) 2011; 63 Huber MA (e_1_2_10_46_1) 2004; 114 Tannheimer S (e_1_2_10_63_1) 1998; 19 Robledo T (e_1_2_10_33_1) 2005; 24 Greer YE (e_1_2_10_40_1) 2019; 21 Hazan RB (e_1_2_10_52_1) 2000; 148 Min C (e_1_2_10_57_1) 2008; 104 Ferlay J (e_1_2_10_2_1) 2021; 149 Wogan GN (e_1_2_10_25_1) 2004; 14 Hodgson L (e_1_2_10_35_1) 2003; 22 Lyons TG (e_1_2_10_7_1) 2019; 20 Faustino‐Rocha A (e_1_2_10_39_1) 2013; 42 Harbeck N (e_1_2_10_3_1) 2019; 5 Wei D (e_1_2_10_4_1) 2016; 3 Rundle A (e_1_2_10_24_1) 2000; 21 Cui N (e_1_2_10_55_1) 2017; 147 |
References_xml | – volume: 9 issue: suppl 1 year: 2015 article-title: Targeting breast cancer metastasis publication-title: Breast Cancer Basic Clin Res – volume: 15 start-page: 201 issue: 2 year: 2010 end-page: 212 article-title: Matrix metalloproteinase‐induced epithelial‐mesenchymal transition in breast cancer publication-title: J Mammary Gland Biol Neoplasia – volume: 149 year: 2021 article-title: Risk of breast cancer associated with long‐term exposure to benzo[a]pyrene (BaP) air pollution: evidence from the French E3N cohort study publication-title: Environ Int – volume: 10 start-page: 179 issue: 2 year: 2020 article-title: FAK structure and regulation by membrane interactions and force in focal adhesions publication-title: Biomolecules – volume: 104 start-page: 733 issue: 3 year: 2008 end-page: 744 article-title: NF‐κB and epithelial to mesenchymal transition of cancer publication-title: J Cell Biochem – volume: 63 start-page: 610 issue: 8 year: 2011 end-page: 615 article-title: Focal adhesion kinase and its signaling pathways in cell migration and angiogenesis publication-title: Adv Drug Deliv Rev – volume: 184 start-page: 467 year: 2017 end-page: 472 article-title: Study on the occurrence of polycyclic aromatic hydrocarbons in milk and meat/fish based baby food available in Italy publication-title: Chemosphere – volume: 234 start-page: 201 issue: 3 year: 2015 end-page: 210 article-title: Effects of exposure to benzo[a]pyrene on metastasis of breast cancer are mediated through ROS‐ERK‐MMP9 axis signaling publication-title: Toxicol Lett – volume: 23 start-page: vi46 issue: suppl 6 year: 2012 end-page: vi51 article-title: Optimal strategies for the treatment of metastatic triple‐negative breast cancer with currently approved agents publication-title: Ann Oncol – volume: 9 issue: 5 year: 2014 article-title: Development and characterization of a preclinical model of breast cancer lung micrometastatic to macrometastatic progression publication-title: PLoS One – volume: 114 start-page: 569 issue: 4 year: 2004 end-page: 581 article-title: NF‐κB is essential for epithelial‐mesenchymal transition and metastasis in a model of breast cancer progression publication-title: J Clin Invest – volume: 149 start-page: 778 issue: 4 year: 2021 end-page: 789 article-title: Cancer statistics for the year 2020: an overview publication-title: Int J Cancer – volume: 20 start-page: 82 issue: 11 year: 2019 article-title: Targeted therapies for triple‐negative breast cancer publication-title: Curr Treat Options Oncol – volume: 29 start-page: 303 issue: 4 year: 2013 end-page: 319 article-title: Benzo‐[a]‐pyrene induces FAK activation and cell migration in MDA‐MB‐231 breast cancer cells publication-title: Cell Biol Toxicol – volume: 72 start-page: 1 issue: 1 year: 2014 end-page: 17 article-title: Breast cancer and dietary patterns: a systematic review publication-title: Nutr Res – volume: 2014 start-page: 655 issue: 6 year: 2014 end-page: 658 article-title: Manual hematoxylin and eosin staining of mouse tissue sections publication-title: Cold Spring Harbor protocols – volume: 17 start-page: 499 issue: 5 year: 2005 end-page: 508 article-title: Cadherins and catenins in breast cancer publication-title: Curr Opin Cell Biol – volume: 15 start-page: 740 issue: 6 year: 2003 end-page: 746 article-title: Epithelial‐mesenchymal transitions in development and pathologies publication-title: Curr Opin Cell Biol – volume: 63 start-page: 2658 issue: 10 year: 2003 end-page: 2664 article-title: Transactivation of vimentin by beta‐catenin in human breast cancer cells publication-title: Cancer Res – volume: 21 start-page: 27 issue: 1 year: 2019 article-title: MEDI3039, a novel highly potent tumor necrosis factor (TNF)‐related apoptosis‐inducing ligand (TRAIL) receptor 2 agonist, causes regression of orthotopic tumors and inhibits outgrowth of metastatic triple‐negative breast cancer publication-title: Breast Cancer Res – volume: 6 start-page: 154 issue: 2 year: 2004 end-page: 161 article-title: FAK‐Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly publication-title: Nat Cell Biol – volume: 2 start-page: 76 issue: 2 year: 2000 end-page: 83 article-title: The transcription factor snail controls epithelial‐mesenchymal transitions by repressing e‐cadherin expression publication-title: Nat Cell Biol – volume: 6 start-page: 622 issue: 8 year: 2005 end-page: 634 article-title: Regulation of cadherin‐mediated adhesion in morphogenesis publication-title: Nat Rev Mol Cell Biol – volume: 42 start-page: 217 issue: 6 year: 2013 end-page: 224 article-title: Estimation of rat mammary tumor volume using caliper and ultrasonography measurements publication-title: Lab Anim – volume: 37 start-page: 752 issue: 7 year: 2018 end-page: 761 article-title: Benzo(a)pyrene induces lung toxicity and inflammation in mice: prevention by carvacrol publication-title: Hum Exp Toxicol – volume: 5 start-page: 66 issue: 1 year: 2019 article-title: Breast cancer publication-title: Nat Rev Dis Primers – volume: 39 start-page: 375 issue: 2 year: 2019 end-page: 384 article-title: Invasion and migration of MDA‐MB‐231 cells are inhibited by block of AhR and NFAT: role of AhR/NFAT1/β4 integrin signaling publication-title: J Appl Toxicol – volume: 139 start-page: 871 issue: 5 year: 2009 end-page: 890 article-title: Epithelial‐mesenchymal transitions in development and disease publication-title: Cell – volume: 39 start-page: 423 issue: 5 year: 2001 end-page: 436 article-title: Analysis of 200 food items for benzo[a]pyrene and estimation of its intake in an epidemiologic study publication-title: Food Chem Toxicol – volume: 575 year: 2023 article-title: Bisphenol A increases the size of primary mammary tumors and promotes metastasis in a murine model of breast cancer publication-title: Mol Cell Endocrinol – volume: 3 start-page: 362 issue: 5 year: 2003 end-page: 374 article-title: Tumour‐cell invasion and migration: diversity and escape mechanisms publication-title: Nat Rev Cancer – volume: 7 start-page: 20381 issue: 15 year: 2016 end-page: 20394 article-title: MiR‐148a functions to suppress metastasis and serves as a prognostic indicator in triple‐negative breast cancer publication-title: Oncotarget – volume: 28 start-page: 2236 issue: 10 year: 2007 end-page: 2243 article-title: Potent carcinogenicity of cigarette smoke in mice exposed early in life publication-title: Carcinogenesis – volume: 48 start-page: 365 issue: 5‐6 year: 2004 end-page: 375 article-title: Transcriptional regulation of cadherins during development and carcinogenesis publication-title: Int J Dev Biol – volume: 294 start-page: 11 year: 2018 end-page: 19 article-title: Benzo(a)pyrene promotes migration, invasion and metastasis of lung adenocarcinoma cells by upregulating TGIF publication-title: Toxicol Lett – volume: 67 start-page: 1265 issue: 7 year: 2007 end-page: 1274 article-title: Polycyclic aromatic hydrocarbons (PAHs) in human milk from Italian women: influence of cigarette smoking and residential area publication-title: Chemosphere – volume: 384 start-page: 6 issue: 1 year: 2009 end-page: 11 article-title: Molecular mechanisms controlling e‐cadherin expression in breast cancer publication-title: Biochem Biophys Res Commun – volume: 1 start-page: 303 issue: 6‐7 year: 2009 end-page: 314 article-title: Inflammation and EMT: an alliance towards organ fibrosis and cancer progression publication-title: EMBO Mol Med – volume: 40 start-page: 1187 issue: 4 year: 2020 end-page: 1195 article-title: Contamination and daily intake of polycyclic aromatic hydrocarbons in Iranian bread samples publication-title: Polycyclic Aromat Compd – volume: 14 start-page: 473 issue: 6 year: 2004 end-page: 486 article-title: Environmental and chemical carcinogenesis publication-title: Sem Cancer Biol – volume: 16 start-page: 6 issue: 1 year: 2017 article-title: IGF‐IR signaling in epithelial to mesenchymal transition and targeting IGF‐IR therapy: overview and new insights publication-title: Mol Cancer – volume: 14 start-page: 199 issue: 5 year: 2008 end-page: 209 article-title: Epithelial‐mesenchymal transition and the invasive potential of tumors publication-title: Trends Mol Med – volume: 147 start-page: 1 year: 2017 end-page: 73 article-title: Biochemical and biological attributes of matrix metalloproteinases publication-title: Prog Mol Biol Transl Sci – volume: 24 start-page: 469 issue: 7 year: 2005 end-page: 477 article-title: Type IV collagen induces STAT5 activation in MCF7 human breast cancer cells publication-title: Matrix Biol – volume: 21 start-page: 1281 issue: 7 year: 2000 end-page: 1289 article-title: The relationship between genetic damage from polycyclic aromatic hydrocarbons in breast tissue and breast cancer publication-title: Carcinogenesis – volume: 12 start-page: 2342 issue: 9 year: 2020 article-title: P2X7 receptor promotes mouse mammary cancer cell invasiveness and tumour progression, and is a target for anticancer treatment publication-title: Cancers – volume: 23 start-page: 6806 issue: 12 year: 2022 article-title: Breast cancer metastasis: mechanisms and therapeutic implications publication-title: Int J Mol Sci – volume: 148 start-page: 779 issue: 4 year: 2000 end-page: 790 article-title: Exogenous expression of n‐cadherin in breast cancer cells induces cell migration, invasion, and metastasis publication-title: J Cell Biol – volume: 70 start-page: 1391 issue: 15‐16 year: 2007 end-page: 1394 article-title: Dietary exposure estimation of benzo[a]pyrene and cancer risk assessment publication-title: J Toxicol Env Health A – volume: 18 start-page: 1135 issue: 5 year: 2000 article-title: Matrix metalloproteinases: biologic activity and clinical implications publication-title: J Clin Oncol – volume: 2 start-page: 563 issue: 8 year: 2002 end-page: 572 article-title: Dissemination and growth of cancer cells in metastatic sites publication-title: Nat Rev Cancer – volume: 22 start-page: 98 issue: 1 year: 2003 end-page: 108 article-title: Melanoma cell migration to type IV collagen requires activation of NF‐κB publication-title: Oncogene – volume: 21 start-page: 149 issue: 1 year: 2021 article-title: Prognostic values of tumoral MMP2 and MMP9 overexpression in breast cancer: a systematic review and meta‐analysis publication-title: BMC Cancer – volume: 38 start-page: 2141 issue: 4 year: 2017 end-page: 2147 article-title: Benzo(a)pyrene enhances the EMT‐associated migration of lung adenocarcinoma A549 cells by upregulating Twist1 publication-title: Oncol Rep – volume: 3 start-page: 226 issue: 3 year: 2016 end-page: 232 article-title: Effectiveness of physical, psychological, social, and spiritual intervention in breast cancer survivors: an integrative review publication-title: Asia Pac J Oncol Nurs – volume: 18 start-page: 1177 issue: 6 year: 1997 end-page: 1182 article-title: Carcinogenic polycyclic aromatic hydrocarbons increase intracellular Ca2+ and cell proliferation in primary human mammary epithelial cells publication-title: Carcinogenesis – volume: 23 issue: 11 year: 2022 article-title: Benzo[a]pyrene‐Environmental occurrence, human exposure, and mechanisms of toxicity publication-title: Int J Mol Sci – volume: 38 start-page: 689 issue: 6 year: 2012 end-page: 697 article-title: Epithelial‐mesenchymal transition and breast cancer: role, molecular mechanisms and clinical impact publication-title: Cancer Treat Rev – volume: 45 start-page: 741 issue: 2 year: 2022 end-page: 749 article-title: Benzo(a)pyrene affects proliferation with reference to metabolic genes and ROS/HIF‐1α/HO‐1 signaling in A549 and MCF‐7 cancer cells publication-title: Drug Chem Toxicol – volume: 17 start-page: 542 issue: 5 year: 2005 end-page: 547 article-title: Src and FAK signalling controls adhesion fate and the epithelial‐to‐mesenchymal transition publication-title: Curr Opin Cell Biol – volume: 19 start-page: 1291 issue: 7 year: 1998 end-page: 1297 article-title: Benzo[a]pyrene‐ and TCDD‐induced alterations in tyrosine phosphorylation and insulin‐like growth factor signaling pathways in the MCF‐10A human mammary epithelial cell line publication-title: Carcinogenesis – volume: 49 start-page: 361 issue: 3 year: 2019 end-page: 374 article-title: Epithelial‐Mesenchymal plasticity in cancer progression and metastasis publication-title: Dev Cell – volume: 92 start-page: 3223 issue: 10 year: 2018 end-page: 3239 article-title: Mechanistic evidence that benzo[a]pyrene promotes an inflammatory microenvironment that drives the metastatic potential of human mammary cells publication-title: Arch Toxicol – volume: 149 start-page: 778 issue: 4 year: 2021 ident: e_1_2_10_2_1 article-title: Cancer statistics for the year 2020: an overview publication-title: Int J Cancer doi: 10.1002/ijc.33588 contributor: fullname: Ferlay J – volume: 149 year: 2021 ident: e_1_2_10_26_1 article-title: Risk of breast cancer associated with long‐term exposure to benzo[a]pyrene (BaP) air pollution: evidence from the French E3N cohort study publication-title: Environ Int doi: 10.1016/j.envint.2021.106399 contributor: fullname: Amadou A – volume: 9 issue: 5 year: 2014 ident: e_1_2_10_37_1 article-title: Development and characterization of a preclinical model of breast cancer lung micrometastatic to macrometastatic progression publication-title: PLoS One doi: 10.1371/journal.pone.0098624 contributor: fullname: Bailey‐Downs LC – volume: 6 start-page: 622 issue: 8 year: 2005 ident: e_1_2_10_18_1 article-title: Regulation of cadherin‐mediated adhesion in morphogenesis publication-title: Nat Rev Mol Cell Biol doi: 10.1038/nrm1699 contributor: fullname: Gumbiner BM – volume: 7 start-page: 20381 issue: 15 year: 2016 ident: e_1_2_10_41_1 article-title: MiR‐148a functions to suppress metastasis and serves as a prognostic indicator in triple‐negative breast cancer publication-title: Oncotarget doi: 10.18632/oncotarget.7953 contributor: fullname: Xu X – volume: 22 start-page: 98 issue: 1 year: 2003 ident: e_1_2_10_35_1 article-title: Melanoma cell migration to type IV collagen requires activation of NF‐κB publication-title: Oncogene doi: 10.1038/sj.onc.1206059 contributor: fullname: Hodgson L – volume: 16 start-page: 6 issue: 1 year: 2017 ident: e_1_2_10_13_1 article-title: IGF‐IR signaling in epithelial to mesenchymal transition and targeting IGF‐IR therapy: overview and new insights publication-title: Mol Cancer doi: 10.1186/s12943-016-0576-5 contributor: fullname: Li H – volume: 294 start-page: 11 year: 2018 ident: e_1_2_10_64_1 article-title: Benzo(a)pyrene promotes migration, invasion and metastasis of lung adenocarcinoma cells by upregulating TGIF publication-title: Toxicol Lett doi: 10.1016/j.toxlet.2018.05.005 contributor: fullname: Yang H – volume: 29 start-page: 303 issue: 4 year: 2013 ident: e_1_2_10_31_1 article-title: Benzo‐[a]‐pyrene induces FAK activation and cell migration in MDA‐MB‐231 breast cancer cells publication-title: Cell Biol Toxicol doi: 10.1007/s10565-013-9254-1 contributor: fullname: Castillo‐Sanchez R – volume: 92 start-page: 3223 issue: 10 year: 2018 ident: e_1_2_10_30_1 article-title: Mechanistic evidence that benzo[a]pyrene promotes an inflammatory microenvironment that drives the metastatic potential of human mammary cells publication-title: Arch Toxicol doi: 10.1007/s00204-018-2291-z contributor: fullname: Malik D – volume: 72 start-page: 1 issue: 1 year: 2014 ident: e_1_2_10_5_1 article-title: Breast cancer and dietary patterns: a systematic review publication-title: Nutr Res contributor: fullname: Albuquerque RC – volume: 15 start-page: 201 issue: 2 year: 2010 ident: e_1_2_10_53_1 article-title: Matrix metalloproteinase‐induced epithelial‐mesenchymal transition in breast cancer publication-title: J Mammary Gland Biol Neoplasia doi: 10.1007/s10911-010-9177-x contributor: fullname: Radisky ES – volume: 23 start-page: vi46 issue: 6 year: 2012 ident: e_1_2_10_8_1 article-title: Optimal strategies for the treatment of metastatic triple‐negative breast cancer with currently approved agents publication-title: Ann Oncol doi: 10.1093/annonc/mds195 contributor: fullname: André F – volume: 3 start-page: 226 issue: 3 year: 2016 ident: e_1_2_10_4_1 article-title: Effectiveness of physical, psychological, social, and spiritual intervention in breast cancer survivors: an integrative review publication-title: Asia Pac J Oncol Nurs doi: 10.4103/2347-5625.189813 contributor: fullname: Wei D – volume: 38 start-page: 689 issue: 6 year: 2012 ident: e_1_2_10_19_1 article-title: Epithelial‐mesenchymal transition and breast cancer: role, molecular mechanisms and clinical impact publication-title: Cancer Treat Rev doi: 10.1016/j.ctrv.2011.11.001 contributor: fullname: Foroni C – volume: 40 start-page: 1187 issue: 4 year: 2020 ident: e_1_2_10_59_1 article-title: Contamination and daily intake of polycyclic aromatic hydrocarbons in Iranian bread samples publication-title: Polycyclic Aromat Compd doi: 10.1080/10406638.2018.1534747 contributor: fullname: Kamalabadi M – volume: 63 start-page: 610 issue: 8 year: 2011 ident: e_1_2_10_23_1 article-title: Focal adhesion kinase and its signaling pathways in cell migration and angiogenesis publication-title: Adv Drug Deliv Rev doi: 10.1016/j.addr.2010.11.001 contributor: fullname: Zhao X – volume: 20 start-page: 82 issue: 11 year: 2019 ident: e_1_2_10_7_1 article-title: Targeted therapies for triple‐negative breast cancer publication-title: Curr Treat Options Oncol doi: 10.1007/s11864-019-0682-x contributor: fullname: Lyons TG – volume: 45 start-page: 741 issue: 2 year: 2022 ident: e_1_2_10_48_1 article-title: Benzo(a)pyrene affects proliferation with reference to metabolic genes and ROS/HIF‐1α/HO‐1 signaling in A549 and MCF‐7 cancer cells publication-title: Drug Chem Toxicol doi: 10.1080/01480545.2020.1774602 contributor: fullname: Gao M – volume: 234 start-page: 201 issue: 3 year: 2015 ident: e_1_2_10_47_1 article-title: Effects of exposure to benzo[a]pyrene on metastasis of breast cancer are mediated through ROS‐ERK‐MMP9 axis signaling publication-title: Toxicol Lett doi: 10.1016/j.toxlet.2015.02.016 contributor: fullname: Guo J – volume: 184 start-page: 467 year: 2017 ident: e_1_2_10_60_1 article-title: Study on the occurrence of polycyclic aromatic hydrocarbons in milk and meat/fish based baby food available in Italy publication-title: Chemosphere doi: 10.1016/j.chemosphere.2017.06.017 contributor: fullname: Santonicola S – volume: 39 start-page: 375 issue: 2 year: 2019 ident: e_1_2_10_32_1 article-title: Invasion and migration of MDA‐MB‐231 cells are inhibited by block of AhR and NFAT: role of AhR/NFAT1/β4 integrin signaling publication-title: J Appl Toxicol doi: 10.1002/jat.3728 contributor: fullname: Shadboorestan A – volume: 18 start-page: 1135 issue: 5 year: 2000 ident: e_1_2_10_54_1 article-title: Matrix metalloproteinases: biologic activity and clinical implications publication-title: J Clin Oncol doi: 10.1200/JCO.2000.18.5.1135 contributor: fullname: Nelson AR – volume: 37 start-page: 752 issue: 7 year: 2018 ident: e_1_2_10_58_1 article-title: Benzo(a)pyrene induces lung toxicity and inflammation in mice: prevention by carvacrol publication-title: Hum Exp Toxicol doi: 10.1177/0960327117735572 contributor: fullname: Barnwal P – volume: 49 start-page: 361 issue: 3 year: 2019 ident: e_1_2_10_14_1 article-title: Epithelial‐Mesenchymal plasticity in cancer progression and metastasis publication-title: Dev Cell doi: 10.1016/j.devcel.2019.04.010 contributor: fullname: Lu W – volume: 70 start-page: 1391 issue: 15 year: 2007 ident: e_1_2_10_28_1 article-title: Dietary exposure estimation of benzo[a]pyrene and cancer risk assessment publication-title: J Toxicol Env Health A contributor: fullname: Lee BM – volume: 21 start-page: 27 issue: 1 year: 2019 ident: e_1_2_10_40_1 article-title: MEDI3039, a novel highly potent tumor necrosis factor (TNF)‐related apoptosis‐inducing ligand (TRAIL) receptor 2 agonist, causes regression of orthotopic tumors and inhibits outgrowth of metastatic triple‐negative breast cancer publication-title: Breast Cancer Res doi: 10.1186/s13058-019-1116-1 contributor: fullname: Greer YE – volume: 67 start-page: 1265 issue: 7 year: 2007 ident: e_1_2_10_49_1 article-title: Polycyclic aromatic hydrocarbons (PAHs) in human milk from Italian women: influence of cigarette smoking and residential area publication-title: Chemosphere doi: 10.1016/j.chemosphere.2006.12.011 contributor: fullname: Zanieri L – volume: 19 start-page: 1291 issue: 7 year: 1998 ident: e_1_2_10_63_1 article-title: Benzo[a]pyrene‐ and TCDD‐induced alterations in tyrosine phosphorylation and insulin‐like growth factor signaling pathways in the MCF‐10A human mammary epithelial cell line publication-title: Carcinogenesis doi: 10.1093/carcin/19.7.1291 contributor: fullname: Tannheimer S – volume: 5 start-page: 66 issue: 1 year: 2019 ident: e_1_2_10_3_1 article-title: Breast cancer publication-title: Nat Rev Dis Primers doi: 10.1038/s41572-019-0111-2 contributor: fullname: Harbeck N – volume: 9 issue: 1 year: 2015 ident: e_1_2_10_6_1 article-title: Targeting breast cancer metastasis publication-title: Breast Cancer Basic Clin Res doi: 10.4137/BCBCR.S25460 contributor: fullname: Jin X – volume: 48 start-page: 365 issue: 5 year: 2004 ident: e_1_2_10_17_1 article-title: Transcriptional regulation of cadherins during development and carcinogenesis publication-title: Int J Dev Biol doi: 10.1387/ijdb.041794hp contributor: fullname: Peinado H – volume: 21 start-page: 149 issue: 1 year: 2021 ident: e_1_2_10_56_1 article-title: Prognostic values of tumoral MMP2 and MMP9 overexpression in breast cancer: a systematic review and meta‐analysis publication-title: BMC Cancer doi: 10.1186/s12885-021-07860-2 contributor: fullname: Jiang H – volume: 17 start-page: 499 issue: 5 year: 2005 ident: e_1_2_10_45_1 article-title: Cadherins and catenins in breast cancer publication-title: Curr Opin Cell Biol doi: 10.1016/j.ceb.2005.08.014 contributor: fullname: Cowin P – volume: 42 start-page: 217 issue: 6 year: 2013 ident: e_1_2_10_39_1 article-title: Estimation of rat mammary tumor volume using caliper and ultrasonography measurements publication-title: Lab Anim doi: 10.1038/laban.254 contributor: fullname: Faustino‐Rocha A – volume: 12 start-page: 2342 issue: 9 year: 2020 ident: e_1_2_10_38_1 article-title: P2X7 receptor promotes mouse mammary cancer cell invasiveness and tumour progression, and is a target for anticancer treatment publication-title: Cancers doi: 10.3390/cancers12092342 contributor: fullname: Brisson L – volume: 23 start-page: 6806 issue: 12 year: 2022 ident: e_1_2_10_9_1 article-title: Breast cancer metastasis: mechanisms and therapeutic implications publication-title: Int J Mol Sci doi: 10.3390/ijms23126806 contributor: fullname: Park M – volume: 24 start-page: 469 issue: 7 year: 2005 ident: e_1_2_10_33_1 article-title: Type IV collagen induces STAT5 activation in MCF7 human breast cancer cells publication-title: Matrix Biol doi: 10.1016/j.matbio.2005.07.004 contributor: fullname: Robledo T – volume: 575 year: 2023 ident: e_1_2_10_36_1 article-title: Bisphenol A increases the size of primary mammary tumors and promotes metastasis in a murine model of breast cancer publication-title: Mol Cell Endocrinol doi: 10.1016/j.mce.2023.111998 contributor: fullname: Torres‐Alamilla P – volume: 17 start-page: 542 issue: 5 year: 2005 ident: e_1_2_10_22_1 article-title: Src and FAK signalling controls adhesion fate and the epithelial‐to‐mesenchymal transition publication-title: Curr Opin Cell Biol doi: 10.1016/j.ceb.2005.08.007 contributor: fullname: Avizienyte E – volume: 14 start-page: 199 issue: 5 year: 2008 ident: e_1_2_10_12_1 article-title: Epithelial‐mesenchymal transition and the invasive potential of tumors publication-title: Trends Mol Med doi: 10.1016/j.molmed.2008.03.004 contributor: fullname: Gavert N – volume: 139 start-page: 871 issue: 5 year: 2009 ident: e_1_2_10_10_1 article-title: Epithelial‐mesenchymal transitions in development and disease publication-title: Cell doi: 10.1016/j.cell.2009.11.007 contributor: fullname: Thiery JP – volume: 63 start-page: 2658 issue: 10 year: 2003 ident: e_1_2_10_51_1 article-title: Transactivation of vimentin by beta‐catenin in human breast cancer cells publication-title: Cancer Res contributor: fullname: Gilles C – volume: 104 start-page: 733 issue: 3 year: 2008 ident: e_1_2_10_57_1 article-title: NF‐κB and epithelial to mesenchymal transition of cancer publication-title: J Cell Biochem doi: 10.1002/jcb.21695 contributor: fullname: Min C – volume: 3 start-page: 362 issue: 5 year: 2003 ident: e_1_2_10_20_1 article-title: Tumour‐cell invasion and migration: diversity and escape mechanisms publication-title: Nat Rev Cancer doi: 10.1038/nrc1075 contributor: fullname: Friedl P – volume: 1 start-page: 303 issue: 6 year: 2009 ident: e_1_2_10_34_1 article-title: Inflammation and EMT: an alliance towards organ fibrosis and cancer progression publication-title: EMBO Mol Med doi: 10.1002/emmm.200900043 contributor: fullname: López‐Novoa JM – volume: 2014 start-page: 655 issue: 6 year: 2014 ident: e_1_2_10_42_1 article-title: Manual hematoxylin and eosin staining of mouse tissue sections publication-title: Cold Spring Harbor protocols doi: 10.1101/pdb.prot073411 contributor: fullname: Cardiff RD – volume: 6 start-page: 154 issue: 2 year: 2004 ident: e_1_2_10_44_1 article-title: FAK‐Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly publication-title: Nat Cell Biol doi: 10.1038/ncb1094 contributor: fullname: Webb DJ – volume: 38 start-page: 2141 issue: 4 year: 2017 ident: e_1_2_10_50_1 article-title: Benzo(a)pyrene enhances the EMT‐associated migration of lung adenocarcinoma A549 cells by upregulating Twist1 publication-title: Oncol Rep doi: 10.3892/or.2017.5874 contributor: fullname: Chen X – volume: 21 start-page: 1281 issue: 7 year: 2000 ident: e_1_2_10_24_1 article-title: The relationship between genetic damage from polycyclic aromatic hydrocarbons in breast tissue and breast cancer publication-title: Carcinogenesis doi: 10.1093/carcin/21.7.1281 contributor: fullname: Rundle A – volume: 39 start-page: 423 issue: 5 year: 2001 ident: e_1_2_10_61_1 article-title: Analysis of 200 food items for benzo[a]pyrene and estimation of its intake in an epidemiologic study publication-title: Food Chem Toxicol doi: 10.1016/S0278-6915(00)00158-7 contributor: fullname: Kazerouni N – volume: 2 start-page: 76 issue: 2 year: 2000 ident: e_1_2_10_16_1 article-title: The transcription factor snail controls epithelial‐mesenchymal transitions by repressing e‐cadherin expression publication-title: Nat Cell Biol doi: 10.1038/35000025 contributor: fullname: Cano A – volume: 148 start-page: 779 issue: 4 year: 2000 ident: e_1_2_10_52_1 article-title: Exogenous expression of n‐cadherin in breast cancer cells induces cell migration, invasion, and metastasis publication-title: J Cell Biol doi: 10.1083/jcb.148.4.779 contributor: fullname: Hazan RB – volume: 28 start-page: 2236 issue: 10 year: 2007 ident: e_1_2_10_29_1 article-title: Potent carcinogenicity of cigarette smoke in mice exposed early in life publication-title: Carcinogenesis doi: 10.1093/carcin/bgm122 contributor: fullname: Balansky R – volume: 114 start-page: 569 issue: 4 year: 2004 ident: e_1_2_10_46_1 article-title: NF‐κB is essential for epithelial‐mesenchymal transition and metastasis in a model of breast cancer progression publication-title: J Clin Invest doi: 10.1172/JCI200421358 contributor: fullname: Huber MA – volume: 23 issue: 11 year: 2022 ident: e_1_2_10_27_1 article-title: Benzo[a]pyrene‐Environmental occurrence, human exposure, and mechanisms of toxicity publication-title: Int J Mol Sci doi: 10.3390/ijms23116348 contributor: fullname: Bukowska B – volume: 15 start-page: 740 issue: 6 year: 2003 ident: e_1_2_10_11_1 article-title: Epithelial‐mesenchymal transitions in development and pathologies publication-title: Curr Opin Cell Biol doi: 10.1016/j.ceb.2003.10.006 contributor: fullname: Thiery JP – volume: 10 start-page: 179 issue: 2 year: 2020 ident: e_1_2_10_43_1 article-title: FAK structure and regulation by membrane interactions and force in focal adhesions publication-title: Biomolecules doi: 10.3390/biom10020179 contributor: fullname: Tapial Martínez P – volume: 18 start-page: 1177 issue: 6 year: 1997 ident: e_1_2_10_62_1 article-title: Carcinogenic polycyclic aromatic hydrocarbons increase intracellular Ca2+ and cell proliferation in primary human mammary epithelial cells publication-title: Carcinogenesis doi: 10.1093/carcin/18.6.1177 contributor: fullname: Tannheimer S – volume: 384 start-page: 6 issue: 1 year: 2009 ident: e_1_2_10_15_1 article-title: Molecular mechanisms controlling e‐cadherin expression in breast cancer publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2009.04.051 contributor: fullname: Baranwal S – volume: 14 start-page: 473 issue: 6 year: 2004 ident: e_1_2_10_25_1 article-title: Environmental and chemical carcinogenesis publication-title: Sem Cancer Biol doi: 10.1016/j.semcancer.2004.06.010 contributor: fullname: Wogan GN – volume: 2 start-page: 563 issue: 8 year: 2002 ident: e_1_2_10_21_1 article-title: Dissemination and growth of cancer cells in metastatic sites publication-title: Nat Rev Cancer doi: 10.1038/nrc865 contributor: fullname: Chambers AF – volume: 147 start-page: 1 year: 2017 ident: e_1_2_10_55_1 article-title: Biochemical and biological attributes of matrix metalloproteinases publication-title: Prog Mol Biol Transl Sci doi: 10.1016/bs.pmbts.2017.02.005 contributor: fullname: Cui N |
SSID | ssj0011750 |
Score | 2.4409816 |
Snippet | Breast cancer is the most frequent neoplasia in developed countries and the leading cause of death in women worldwide. Epithelial‐to‐mesenchymal transition... Breast cancer is the most frequent neoplasia in developed countries and the leading cause of death in women worldwide. Epithelial-to-mesenchymal transition... Abstract Breast cancer is the most frequent neoplasia in developed countries and the leading cause of death in women worldwide. Epithelial‐to‐mesenchymal... |
SourceID | proquest crossref pubmed wiley |
SourceType | Aggregation Database Index Database Publisher |
StartPage | 1319 |
SubjectTerms | Animals B[a]P Benzo(a)pyrene - toxicity Brain Neoplasms - chemically induced Brain Neoplasms - pathology Brain Neoplasms - secondary breast cancer Breast Neoplasms - chemically induced Breast Neoplasms - pathology Cell Line, Tumor Cell Proliferation - drug effects EMT Epithelial-Mesenchymal Transition - drug effects Female Humans mammary tumors metastasis Mice Mice, Inbred BALB C |
Title | Benzo[a]pyrene promotes an epithelial‐to‐mesenchymal transition process in MCF10A cells and mammary tumor growth and brain metastasis in female mice |
URI | https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fmc.23726 https://www.ncbi.nlm.nih.gov/pubmed/38629425 https://www.proquest.com/docview/3040322107/abstract/ |
Volume | 63 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1LS-RAEG50ZMWLrI_V0V1pQbxFk06nkznOzioizLKIgrAsoZ-OYB44mcN48ifscX-fv8Sqzswssix4SQ7prpBUddVX3fUg5CgJTcqEtUFP6yzg2iWBSrEloET7ZAx3ApOTh9_FxQ2_vE1uZ1GVmAvT1odYbLjhyvD6Ghe4VOPTv0VDC33CYnjPMlkBVJOhRDP-Y3GCAGbR76-APxGgYz0vPBuy0_nMt6boH3z5Fq56e3P-kazPgCLtt5zdIEu23CQf2taR002yOpwdim-RP19t-VT9lL_qKdanpLWPsLNjKktqa8y5eAAhe3n-3VRwKTDdSI-mBRBv0FD5mC1atwkD9L6kwwF42X2KW_pIw9BC-gQ32kyK6pHegePejPwDhf0laGEbCRhzfO9nOwuULcUu99vk5vzsenARzBouBBo8LxFIEcaK8dQ4QFURNywSzkVCpMpJbkLnsggGGh1nUmqVWCsSbpOeVDJNnAp78SfSKavS7hKaxgakIDLggGqehDZTqWFcOiMcM6A0uuRw_u_zuq2rkbcVlFle6NzzB8bMmZKD0ONny9JWk3Eeg-oBTQSua5fstNxaUInBR-uBJuqSY8--_5LPhwN_33vvwH2yxgDStMG6n0mneZzYLwBJGnXgZQ-u367YKwCe4LU |
link.rule.ids | 315,786,790,1382,11589,27957,27958,46087,46329,46511,46753 |
linkProvider | Wiley-Blackwell |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Jb9QwFH4qRSwXllJgWI2EuGWaxXZmxKmMqAZoekCtVAlQ5JVWkEUzGaHpiZ_Akd_HL-HZngwqCAlxSQ6xX-L4rfZ7nwGesljnKTcmGis1iqiyLJK5OxJQOPukNbXcFScXB3x6RF8fs-MNeN7XwgR8iPWCm5MMr6-dgLsF6Z1fqKGVGqYZvugCXERpZz6eervGjnIQlH6BBQOKyEXWPfJsnO70Pc_boj8czPP-qjc4e9fhff-pIc_k03DRyaE6-w3F8T_HcgOurRxRshs45yZsmHoLLoWjKZdbcLlYbbrfgu8vTH3WvBMf2qXDvyStz-AzcyJqYlpX0_EZmfjH129dg5fKlTOpk2WFxDtnCH1OGGlDQQI5rUkxwSh-l7gtA0dDk0r4AjrSLapmRj7Omi_diX8g3fkVpDKdQB92fup7W4OUDalQwW3D0d7Lw8k0Wh3oECmM7HgkeJzJlObaoteWUJ0m3NqE81xaQXVs7SjBhlplIyGUZMZwRg0bCylyZmU8zm7DZt3U5i6QPNPIZYnGAFdRFpuRzHVKhdXcphqV0gCe9FNbtgG3owwIzWlZqdL_bGzTz3mJQuWGLWrTLOZlhqoNNR2GxgO4E5hhTSXDGHCMmm4Az_yU_pV8WUz8_d6_NnwMV6aHxX65_-rgzX24mqL7FBKDH8BmN1uYh-j-dPKRZ_OfQewDjA |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwEB5BEVUvFAqUpTyMhLhlmziOs3ssW1blsRVCVKpUochPWrV5aDcrtD3xEzjy-_gljO3NooKQEJfkEHsSx-N52DPfADzPYp1Tbkw0VGoQMWWzSOauJKBw-klrZrlLTp4c8oMj9uY4O15GVbpcmIAPsdpwcyvDy2u3wBttd3-BhpaqT1N8z3W4wXhKHUfvf1hBRzkESr-_gv5E5BzrDng2prtdz6uq6A_78qq56vXNeBNOui8NYSbn_Xkr--ryNxDH_xvKbbi1NEPJXuCbO3DNVFtwMxSmXGzB-mR55H4Xvr801WV9Ij41C4d-SRofv2dmRFTENC6j4wJZ-MfXb22Nl9IlM6nTRYnEW6cGfUQYaUI6AjmryGSEPvwecQcGjoYmpfDpc6Sdl_WUfJ7WX9pT_0C66hWkNK1AC3Z25ntbg5QNKVG83YOj8auPo4NoWc4hUujX8UjwOJWU5dqizZYwTRNubcJ5Lq1gOrZ2kGBDrdKBEEpmxvCMmWwopMgzK-Nheh_WqroyD4DkqUYeSzS6t4plsRnIXFMmrOaWahRJPXjWzWzRBNSOIuAz06JUhf_Z2Kab8gKXlBu2qEw9nxUpCjaUc-gY92A78MKKSooe4BDlXA9e-Bn9K_liMvL3h__a8Cmsv98fF-9eH77dgQ2KtlOICn4Ea-10bh6j7dPKJ57JfwJEoAI7 |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Benzo%5B+a+%5Dpyrene+promotes+an+epithelial%E2%80%90to%E2%80%90mesenchymal+transition+process+in+MCF10A+cells+and+mammary+tumor+growth+and+brain+metastasis+in+female+mice&rft.jtitle=Molecular+carcinogenesis&rft.au=Castillo%E2%80%90Sanchez%2C+Rocio&rft.au=Garcia%E2%80%90Hernandez%2C+Alejandra&rft.au=Torres%E2%80%90Alamilla%2C+Pablo&rft.au=Cortes%E2%80%90Reynosa%2C+Pedro&rft.date=2024-07-01&rft.issn=0899-1987&rft.eissn=1098-2744&rft_id=info:doi/10.1002%2Fmc.23726&rft.externalDBID=n%2Fa&rft.externalDocID=10_1002_mc_23726 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0899-1987&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0899-1987&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0899-1987&client=summon |