Simultaneous quantitation of urine aldosterone and tetrahydroaldosterone in healthy Chinese subjects using a validated LC–MS/MS method

• Published in: Biomedical chromatography Vol. 37; no. 9; pp. e5694 - n/a
• Main Authors: Cheng, Jenny Yeuk Ki, Lo, Clara Wai Shan, Chan, Alan Shek Lun, Luk, Yue Kin, Tsui, Teresa Kam Chi, Ho, Chung Shun
• Format: Journal Article
• Language: English
• Published: England 01.09.2023
• Subjects: aldosterone; LC–MS/MS; tetrahydroaldosterone; LC-MS/MS; aldosterone; tetrahydroaldosterone

Aldosterone (ALD) is excreted in urine mainly as glucuronide conjugates of ALD and tetrahydroaldosterone. Measuring these urinary metabolites might be an alternative screening test to plasma ALD for primary aldosteronism. We report a validated LC–MS/MS method to measure both analytes simultaneously....