The antigenic binding site(s) of antibodies to factor XII associated with the antiphospholipid syndrome

• Published in: Journal of thrombosis and haemostasis Vol. 3; no. 5; pp. 969 - 975
• Main Authors: HARRIS, S. L., JONES, D. W., GALLIMORE, M. J., NICHOLLS, P. J., WINTER, M.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science Inc 01.05.2005
• Subjects: Amino Acid Sequence; Antibodies - chemistry; antibodies to factor XII; Antigens - chemistry; antiphospholipid antibodies; antiphospholipid syndrome; Antiphospholipid Syndrome - immunology; Antiphospholipid Syndrome - metabolism; Binding Sites; Biotinylation; Catalytic Domain; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; factor XII; Factor XII - chemistry; Factor XII - immunology; Humans; Immunoglobulin G - chemistry; Immunoglobulin M - chemistry; Macromolecular Substances - chemistry; Molecular Sequence Data; MultipinTM peptide synthesis; Multiprotein Complexes - chemistry; Peptides - chemistry; Prekallikrein - chemistry; Protein Conformation; Reproducibility of Results; Silver Staining

Phospholipid binding proteins, including factor XII (FXII), are known to be targeted by antiphospholipid antibodies (aPA). Factor XII antibodies (FXIIab) have been described in some patients with the antiphospholipid syndrome (APS) and have been shown to lead to reduced levels of FXII. The antigenic...