Projection-Based Inference in Randomised Clinical Trials

• Published in: International statistical review Vol. 87; no. 2; pp. 263 - 284
• Main Author: Zhang, Biao
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley 01.08.2019; John Wiley & Sons, Inc
• Subjects: Asymptotic properties; augmented inverse probability weighting; Average treatment effect; clinical trial; Clinical trials; Computer simulation; Covariance; covariate adjustment; efficiency; Estimating techniques; Estimation; E‐ancillarity; Inference; influence function; inverse probability weighting; linear space; Medical research; orthogonal complement; Projection; randomisation; Randomization; regression; Regression analysis; Regression models; unbiased estimating function

Covariate information is often available in randomised clinical trials for each subject prior to treatment assignment and is commonly utilised to make covariate adjustment for baseline characteristics predictive of the outcome in order to increase precision and improve power in the detection of a tr...