Pregnane X receptor gene variant rs7643645 and total mortality in subjects with nonalcoholic fatty liver disease

• Published in: Pharmacogenetics and genomics Vol. 33; no. 2; p. 35
• Main Authors: Käräjämäki, Aki J, Hukkanen, Janne, Ukkola, Olavi
• Format: Journal Article
• Language: English
• Published: United States 01.02.2023
• Subjects: Humans; Liver; Middle Aged; Non-alcoholic Fatty Liver Disease - genetics; Pregnane X Receptor - genetics; Promoter Regions, Genetic - genetics; Receptors, Steroid - genetics

Pregnane X receptor (PXR) gene variants rs7643645 and rs2461823 are reported to associate with clinically and histologically more severe liver injury in nonalcoholic fatty liver disease (NAFLD). It is known that the more progressive the NAFLD, the higher the hepatic and extra-hepatic mortality and m...