Acute and chronic effects of oral enprostil, a synthetic dehydroprostaglandin E2, on uterine contractility

• Published in: Prostaglandins, leukotrienes and essential fatty acids Vol. 36; no. 1; pp. 15 - 19
• Main Author: PULKKINEN, M. O
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier 01.04.1989
• Subjects: Administration, Oral; Biological and medical sciences; Catheters, Indwelling; Dose-Response Relationship, Drug; Double-Blind Method; Enprostil; Female; Fundamental and applied biological sciences. Psychology; Humans; Mammalian female genital system; Menstrual Cycle; Morphology. Physiology; Pressure; Prostaglandins E, Synthetic - administration & dosage; Prostaglandins E, Synthetic - pharmacology; Time Factors; Uterine Contraction - drug effects; Vertebrates: reproduction; Human; Prostaglandin; Uterus; Analog; Female genital system; Woman; Muscle contraction

In acute experiments eleven nonpregnant women received a single oral dose of enprostil (prostaglandin E2 analogue) 35-140 mcg. Uterine activity was measured by a microtransducer-tipped Millar catheter. A single, oral dose of enprostil caused a long-lasting contracture response of the uterus. 3 h aft...