Polymeric microspheres prepared by spraying into compressed carbon dioxide

• Published in: Pharmaceutical research Vol. 12; no. 8; p. 1211
• Main Authors: Bodmeier, R, Wang, H, Dixon, D J, Mawson, S, Johnston, K P
• Format: Journal Article
• Language: English
• Published: United States 01.08.1995
• Subjects: Carbon Dioxide; Chlorpheniramine - chemistry; Drug Compounding - methods; Lactates; Lactic Acid; Microscopy, Electron, Scanning; Microspheres; Particle Size; Polyesters; Polymers; Temperature

The objective was to prepare polymeric microparticles by atomizing organic polymer solutions into a spray chamber containing compressed CO2 (PCA-process) and to study the influence of various process parameters on their morphological characteristics. The swelling of various pharmaceutically acceptab...