Cooperative assistance of a sulfonamide in a proline-mediated direct asymmetric aldol addition

• Published in: New journal of chemistry Vol. 47; no. 36; pp. 1742 - 175
• Main Authors: Kumari, Kiran, Bhati, Meeta, Madhukar, Roopendra Singh, Khan, Akram Gulam Hussain, Janjani, Prachi, Rajagopala Reddy, S, Easwar, Srinivasan
• Format: Journal Article
• Language: English
• Published: Cambridge Royal Society of Chemistry 18.09.2023
• Subjects: Adducts; Aldehydes; Asymmetry; Functional groups; Proline; Sulfonamides

A sulfonamide moiety was introduced at the C-4 position of proline, cis to the -COOH group, to examine a possible intramolecular synergistic interaction between the two functional groups and the consequent influence on the enamine mediated asymmetric aldol reaction. The resultant catalyst was profic...