Deciphering lineage specification during early embryogenesis in mouse gastruloids using multilayered proteomics

• Published in: Cell stem cell Vol. 31; no. 7; pp. 1072 - 1090.e8
• Main Authors: Stelloo, Suzan, Alejo-Vinogradova, Maria Teresa, van Gelder, Charlotte A.G.H., Zijlmans, Dick W., van Oostrom, Marek J., Valverde, Juan Manuel, Lamers, Lieke A., Rus, Teja, Sobrevals Alcaraz, Paula, Schäfers, Tilman, Furlan, Cristina, Jansen, Pascal W.T.C., Baltissen, Marijke P.A., Sonnen, Katharina F., Burgering, Boudewijn, Altelaar, Maarten A.F.M., Vos, Harmjan R., Vermeulen, Michiel
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 05.07.2024
• Subjects: Animals; Cell Differentiation; Cell Lineage; developmental biology; dTAG system; Embryonic Development - genetics; enhancers; Gastrula - metabolism; Gastrulation; gastruloids; Gene Expression Regulation, Developmental; germ layers; Humans; interaction proteomics; Mice; Proteomics; Single-Cell Analysis; somitoids; transcription factors; ZEB2; germ layers; ZEB2; proteomics; enhancers; transcription factors; gastruloids; developmental biology; interaction proteomics; somitoids; dTAG system

Gastrulation is a critical stage in embryonic development during which the germ layers are established. Advances in sequencing technologies led to the identification of gene regulatory programs that control the emergence of the germ layers and their derivatives. However, proteome-based studies of ea...