Validation of limited sampling models (LSM) for estimating AUC in therapeutic drug monitoring--is a separate validation group required?

• Published in: International journal of clinical pharmacology and therapeutics Vol. 45; no. 7; p. 402
• Main Author: Proost, J H
• Format: Journal Article
• Language: English
• Published: Germany 01.07.2007
• Subjects: Area Under Curve; Computer Simulation; Cyclosporine - pharmacokinetics; Drug Monitoring; Humans; Immunosuppressive Agents - pharmacokinetics; Models, Biological; Monte Carlo Method; Reproducibility of Results; Research Design

Limited sampling models (LSM) for estimating AUC in therapeutic drug monitoring are usually validated in a separate group of patients, according to published guidelines. The aim of this study is to evaluate the validation of LSM by comparing independent validation with cross-validation using the pat...