The construction of phosphonate triazolyl by copper()-catalyzed furan dearomatized [3 + 2] cycloaddition

• Published in: Organic & biomolecular chemistry Vol. 2; no. 32; pp. 6319 - 6323
• Main Authors: Wahab, Abdul, Gao, Ziwei, Gou, Jing, Yu, Binxun
• Format: Journal Article
• Language: English
• Published: CAMBRIDGE Royal Soc Chemistry 17.08.2022; Royal Society of Chemistry
• Subjects: Alcohols; Cascade chemical reactions; Chemistry; Chemistry, Organic; Copper; Cycloaddition; Phosphonates; Physical Sciences; Ring opening; Science & Technology; Triazoles; AZIDES; ALKYNES; ANALOGS; CLICK CHEMISTRY; INDOLES

Triazole phosphonates are valuable structural motifs in chemical biology and the subject of growing recent interest. A novel methodology to synthesize triazolyl phosphonates starting from furfuryl phosphonate alcohols and organo-azides was developed. This method involved an intermolecular copper-cat...