Tumor invasiveness is regulated by the concerted function of APC, formins, and Arp2/3 complex

• Published in: iScience Vol. 27; no. 5; p. 109687
• Main Authors: Baro, Lautaro, Almhassneh, Rabeah A., Islam, Asifa, Juanes, M. Angeles
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 17.05.2024
• Subjects: Biochemistry; Biological sciences; Cancer systems biology; Cell biology; Natural sciences; Systems biology; Cell biology; Cancer systems biology; Biochemistry; Biological sciences; Natural sciences; Systems biology

Tumor cell invasion is the initial step in metastasis, the leading cause of death from cancer. Invasion requires protrusive cellular structures that steer the migration of leader cells emanating from the tumor mass toward neighboring tissues. Actin is central to these processes and is therefore the...