Cocrystallization of lenvatinib and temozolomide to improve the performance in terms of stability, dissolution, and tabletability

• Published in: CrystEngComm Vol. 25; no. 29; pp. 4189 - 4198
• Main Authors: Wang, Zhi-Qing, Dai, Xia-Lin, Gu, Dai-Lin, Wu, Chao, Lu, Tong-Bu, Long, Xiang-Tian, Chen, Jia-Mei
• Format: Journal Article
• Language: English
• Published: Cambridge Royal Society of Chemistry 24.07.2023
• Subjects: Crystal structure; Dissolution; Hydrogen bonding; NMR; Nuclear magnetic resonance; Stability analysis

Two anti-melanoma drugs, lenvatinib and temozolomide, were cocrystallized to obtain two drug-drug cocrystal solvates, TMZ-LEN·MeOH (1 : 1 : 1) and TMZ-LEN·EtOH (1 : 1 : 1). They were fully characterized by XRD and thermal analyses, NMR and FTIR spectroscopy. The crystal structure of TMZ-LEN·MeOH sho...