Functional polymorphism of CYCLE underlies the diapause variation in moths

• Published in: Science (American Association for the Advancement of Science) Vol. 388; no. 6750; p. eado2129
• Main Authors: Zheng, Shirui, Wang, Yaohui, Li, Guiyun, Qin, Sheng, Dong, Zhi, Yang, Xu, Xu, Xiaomiao, Fang, Gangqi, Li, Muwang, Zhan, Shuai
• Format: Journal Article
• Language: English
• Published: United States The American Association for the Advancement of Science 29.05.2025
• Subjects: Adaptation; Alleles; Animals; BMAL1 protein; Bombyx - embryology; Bombyx - genetics; Bombyx - physiology; Bombyx mori; Butterflies & moths; Changing environments; Circadian rhythm; Circadian Rhythm - genetics; Circadian rhythms; Climate change; Clock gene; CLOCK Proteins - chemistry; CLOCK Proteins - genetics; Diapause; Diapause, Insect - genetics; Domestication; Dormancy; Environmental changes; Environmental conditions; Frameshift mutation; Gene deletion; Gene loci; Genetic crosses; Genetic diversity; Genome-Wide Association Study; Genomes; Global climate; Hibernation; Insect Proteins - chemistry; Insect Proteins - genetics; Insects; Isoforms; Lepidoptera; Life history; Loci; Molecular modelling; Mutagenesis; Mutation; Phenotype; Phenotypes; Polymorphism; Polymorphism, Genetic; Protein Isoforms - genetics; Range extension; Silk; Speciation; Species; Tropical environment; Tropical environments; Vertebrates

Diapause is a common seasonal adaptive strategy that regulates annual timing in insects. Very few causal loci underlying diapause variation have yet been identified. By leveraging cross-mapping and genome-wide association analysis, we identified the N terminus of the clock protein CYCLE as a major c...