β-Cell Dedifferentiation in HOMA-βlow and HOMA-βhigh Subjects

• Published in: The journal of clinical endocrinology and metabolism Vol. 110; no. 5; p. e1430
• Main Authors: Kang, Fuyun, Zhang, Zhuo, Fu, Hui, Sun, Jiajun, Zhang, Jun, Wang, Qidi
• Format: Journal Article
• Language: English
• Published: United States 22.04.2025
• Subjects: Adult; Aged; Aldehyde Oxidoreductases - metabolism; Cell Dedifferentiation - physiology; Diabetes Mellitus, Type 2 - metabolism; Diabetes Mellitus, Type 2 - pathology; Female; Glucose Transporter Type 2 - metabolism; Homeostasis - physiology; Humans; Insulin Resistance - physiology; Insulin-Secreting Cells - cytology; Insulin-Secreting Cells - metabolism; Insulin-Secreting Cells - pathology; Insulin-Secreting Cells - physiology; Male; Middle Aged; Pancreatic Neoplasms - metabolism; Pancreatic Neoplasms - pathology; Bach2; HOMA-β; β-cell dedifferentiation; type 2 diabetes

β-Cell dedifferentiation ratio is increased in type 2 diabetes; but its direct link to in vivo β-cell function in human remains unclear. The present study was designed to investigate whether β-cell dedifferentiation in situ was closely associated with β-cell function in vivo and to identify targets...