Effects of Hypertriglyceridemia With or Without NEFA Elevation on β-cell Function and Insulin Clearance and Sensitivity

• Published in: The journal of clinical endocrinology and metabolism Vol. 110; no. 3; p. e667
• Main Authors: Tricò, Domenico, Rebelos, Eleni, Astiarraga, Brenno, Baldi, Simona, Scozzaro, Tiziana, Sacchetta, Luca, Chiriacò, Martina, Mari, Andrea, Ferrannini, Ele, Muscelli, Elza, Natali, Andrea
• Format: Journal Article
• Language: English
• Published: United States 18.02.2025
• Subjects: Adult; Blood Glucose - metabolism; Diabetes Mellitus, Type 2; Emulsions; Fat Emulsions, Intravenous - administration & dosage; Fatty Acids, Nonesterified - blood; Fatty Acids, Nonesterified - metabolism; Female; Glucose Tolerance Test; Humans; Hypertriglyceridemia - blood; Hypertriglyceridemia - metabolism; Hypertriglyceridemia - physiopathology; Insulin - blood; Insulin - metabolism; Insulin Resistance - physiology; Insulin Secretion; Insulin-Secreting Cells - drug effects; Insulin-Secreting Cells - metabolism; Insulin-Secreting Cells - physiology; Male; Phospholipids - administration & dosage; Soybean Oil - administration & dosage; Young Adult; insulin sensitivity; nonesterified fatty acids; type 2 diabetes; insulin clearance; hypertriglyceridemia; oral glucose tolerance; insulin secretion

Hypertriglyceridemia is a risk factor for developing type 2 diabetes (T2D) and might contribute to its pathogenesis either directly or through elevation of nonesterified fatty acids (NEFAs). This study aimed at comparing the glucometabolic effects of acute hypertriglyceridemia alone or combined with...