Genetic variance of transforming growth factor β2 gene in conotruncal heart defects

Objective: The aim of this study was to evaluate the association between two haplotype-tag single nucleotide polymorphisms (SNPs) (rs6658835 and rs10495098) of TGF-β2 and conotruncal heart defects (CTDs). Methods: Two polymorphisms of TGF-β2 gene were genotyped by polymerase chain reaction-restricti...

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Published inBiomarkers Vol. 22; no. 3-4; pp. 287 - 290
Main Authors Chen, Yu, Zhang, Rui, Xie, Jun, Li, Yajiao, Shi, Shaoqing, Qian, Hong, Yan, Zhiguo, Rao, Li
Format Journal Article
LanguageEnglish
Published England Taylor & Francis 19.05.2017
Subjects
Case-Control Studies
Child, Preschool
Conotruncal heart defects
Female
Gene Frequency
Genetic Variation
Genotype
Heart Defects, Congenital - genetics
Humans
Male
Polymorphism, Single Nucleotide
single nucleotide polymorphisms
Transforming Growth Factor beta2 - genetics
transforming growth factor β2
single nucleotide polymorphisms
transforming growth factor β2
Conotruncal heart defects
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Abstract Objective: The aim of this study was to evaluate the association between two haplotype-tag single nucleotide polymorphisms (SNPs) (rs6658835 and rs10495098) of TGF-β2 and conotruncal heart defects (CTDs). Methods: Two polymorphisms of TGF-β2 gene were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) from 259 CTDs patients and 310 control subjects. Results: The association between SNP rs6658835 in TGF-β2 and CTDs has been found. The frequency of G allele in CTDs patients was significantly higher than that in control subjects (52.7% versus 40.3%, p < 0.001, OR =1.649). Conclusion: TGF-β2 gene polymorphisms may serve as a novel genetic marker for the risk of CTDs.
AbstractList Objective: The aim of this study was to evaluate the association between two haplotype-tag single nucleotide polymorphisms (SNPs) (rs6658835 and rs10495098) of TGF-β2 and conotruncal heart defects (CTDs). Methods: Two polymorphisms of TGF-β2 gene were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) from 259 CTDs patients and 310 control subjects. Results: The association between SNP rs6658835 in TGF-β2 and CTDs has been found. The frequency of G allele in CTDs patients was significantly higher than that in control subjects (52.7% versus 40.3%, p < 0.001, OR =1.649). Conclusion: TGF-β2 gene polymorphisms may serve as a novel genetic marker for the risk of CTDs.
The aim of this study was to evaluate the association between two haplotype-tag single nucleotide polymorphisms (SNPs) (rs6658835 and rs10495098) of TGF-β2 and conotruncal heart defects (CTDs). Two polymorphisms of TGF-β2 gene were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) from 259 CTDs patients and 310 control subjects. The association between SNP rs6658835 in TGF-β2 and CTDs has been found. The frequency of G allele in CTDs patients was significantly higher than that in control subjects (52.7% versus 40.3%, p < 0.001, OR =1.649). TGF-β2 gene polymorphisms may serve as a novel genetic marker for the risk of CTDs.
The aim of this study was to evaluate the association between two haplotype-tag single nucleotide polymorphisms (SNPs) (rs6658835 and rs10495098) of TGF-β2 and conotruncal heart defects (CTDs).OBJECTIVEThe aim of this study was to evaluate the association between two haplotype-tag single nucleotide polymorphisms (SNPs) (rs6658835 and rs10495098) of TGF-β2 and conotruncal heart defects (CTDs).Two polymorphisms of TGF-β2 gene were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) from 259 CTDs patients and 310 control subjects.METHODSTwo polymorphisms of TGF-β2 gene were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) from 259 CTDs patients and 310 control subjects.The association between SNP rs6658835 in TGF-β2 and CTDs has been found. The frequency of G allele in CTDs patients was significantly higher than that in control subjects (52.7% versus 40.3%, p < 0.001, OR =1.649).RESULTSThe association between SNP rs6658835 in TGF-β2 and CTDs has been found. The frequency of G allele in CTDs patients was significantly higher than that in control subjects (52.7% versus 40.3%, p < 0.001, OR =1.649).TGF-β2 gene polymorphisms may serve as a novel genetic marker for the risk of CTDs.CONCLUSIONTGF-β2 gene polymorphisms may serve as a novel genetic marker for the risk of CTDs.
Author Xie, Jun
Qian, Hong
Li, Yajiao
Rao, Li
Yan, Zhiguo
Zhang, Rui
Chen, Yu
Shi, Shaoqing
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transforming growth factor β2
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SubjectTerms Case-Control Studies
Child, Preschool
Conotruncal heart defects
Female
Gene Frequency
Genetic Variation
Genotype
Heart Defects, Congenital - genetics
Humans
Male
Polymorphism, Single Nucleotide
single nucleotide polymorphisms
Transforming Growth Factor beta2 - genetics
transforming growth factor β2
Title Genetic variance of transforming growth factor β2 gene in conotruncal heart defects
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