Copper-catalyzed oxidative coupling of quinoxalin-2(1H)-ones with alcohols: access to hydroxyalkylation of quinoxalin-2(1H)-ones

• Published in: ORGANIC CHEMISTRY FRONTIERS Vol. 5; no. 23; pp. 3382 - 3390
• Main Authors: Fu, Junhao, Yuan, Jinwei, Zhang, Yue, Xiao, Yongmei, Mao, Pu, Diao, Xiaoqiong, Qu, Lingbo
• Format: Journal Article
• Language: English
• Published: CAMBRIDGE Royal Soc Chemistry 07.12.2018; Royal Society of Chemistry
• Subjects: Alcohol; Alcohols; Atom economy; Catalysis; Chemical synthesis; Chemistry; Chemistry, Organic; Copper; Functional groups; Hydrogen bonds; Organic chemistry; Physical Sciences; Science & Technology; Substrates; OXYGEN; ETHERS; DIRECT FUNCTIONALIZATION; C-C BOND; ARYLATION; H BONDS; NUCLEOPHILIC-ADDITION; N-OXIDES; ADJACENT; GRIGNARD-REAGENTS

An efficient copper-catalyzed protocol for the synthesis of hydroxyl-containing quinoxalin-2(1H)-ones from the radical reaction of quinoxalin-2(1H)-ones with alcohols was developed with moderate to good yields. Quinoxalin-2(1H)-ones were coupled with alkyl radicals through direct catalytic functiona...