The indole nucleus as a selective COX-2 inhibitor and anti-inflammatory agent (2011–2022)

Here we have outlined the recent (2011–2022) developments in the synthesis of modified indomethacin-based analogues for the selective inhibition of COX-2 and then highlighted the synthesis of indoles as inhibitors of other inflammatory mediators such as nitric oxide (NO) radicals, lipoxygenase (LOX)...

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Published inOrganic chemistry frontiers an international journal of organic chemistry Vol. 9; no. 13; pp. 3624 - 3639
Main Authors Nisha, Singh, Snigdha, Sharma, Neera, Chandra, Ramesh
Format Journal Article
LanguageEnglish
Published London Royal Society of Chemistry 28.06.2022
Subjects
Anti-inflammatory agents
COX-2 inhibitors
Indoles
Indomethacin
Inflammation
Interleukins
Lipoxygenase
Liquid oxygen
Nitric oxide
Organic chemistry
Reactive oxygen species
Synthesis
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ISSN2052-4110
2052-4110
DOI10.1039/d2qo00534d

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Summary:Here we have outlined the recent (2011–2022) developments in the synthesis of modified indomethacin-based analogues for the selective inhibition of COX-2 and then highlighted the synthesis of indoles as inhibitors of other inflammatory mediators such as nitric oxide (NO) radicals, lipoxygenase (LOX) enzymes, reactive oxygen species (ROS) and interleukin (IL).
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ISSN:2052-4110
2052-4110
DOI:10.1039/d2qo00534d