Exercise-mediated IL-6 downstream effects modulate brain pathology–can exercise training protocols influence the downstream effects?

• Published in: Frontiers in neurology Vol. 16
• Main Authors: Li, Hezhou, Thirupathi, Anand
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 06.08.2025
• Subjects: brain; interleukin-6; molecular signaling; neurodegeneration; Neurology; physical exercise

The dual role of interleukin-6 (IL-6) as beneficial in physiological conditions and detrimental in pathological conditions has been a subject of research interest since its discovery. This has surpassed the traditional view of IL-6 as a pro-inflammatory cytokine, primarily due to its multifunctional...