Etoposide: conformational and hydration features

• Published in: Magnetic resonance in chemistry Vol. 37; no. 11; pp. 788 - 798
• Main Authors: Zhang, Kangling, Franz, A., Craig Hill, G., Michael McCallum, C., Minch, Michael J.
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.11.1999
• Subjects: 1H NMR; conformation; etoposide; hydration; NMR; NOE; NOESY; relaxation matrix analysis; ROESY

The proton chemical shifts of the anticancer agent etoposide in CD3OD, dry CDCl3 and ‘wet’ CDCl3 were determined and all proton resonances were assigned. The general conformational features of etoposide were determined from NMR coupling constants, truncated NOE measurements, NOESY and ROESY experime...