CD226+ B cells in primary Sjögren’s syndrome: a key player in clinical manifestations and disease pathogenesis

• Published in: Frontiers in immunology Vol. 16; p. 1623774
• Main Authors: Zhao, Ping, Song, Saizhe, Zhang, Song, Peng, Cheng, Cheng, Wei, Chang, Xin, Xie, Changhao, Hu, Zhongli, Liu, Cuiping
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 2025
• Subjects: Adult; Aged; Antigens, Differentiation, B-Lymphocyte - immunology; Antigens, Differentiation, B-Lymphocyte - metabolism; Antigens, Differentiation, T-Lymphocyte - immunology; Antigens, Differentiation, T-Lymphocyte - metabolism; B cells; B-Lymphocytes - immunology; B-Lymphocytes - metabolism; Biomarkers; CD226; costimulatory molecule; cytokines; Cytokines - metabolism; Female; Humans; Killer Cells, Natural - immunology; Lymphocyte Activation; Male; Middle Aged; primary Sjögren’s syndrome; Salivary Glands - immunology; Salivary Glands - metabolism; Sjogren's Syndrome - diagnosis; Sjogren's Syndrome - etiology; Sjogren's Syndrome - immunology; Sjogren's Syndrome - metabolism; T Lineage-Specific Activation Antigen 1; CD226; cytokines; B cells; primary Sjögren’s syndrome; costimulatory molecule

Primary Sjögren's syndrome (pSS) is a systemic autoimmune disorder characterized by lymphocytic infiltration of exocrine glands, leading to sicca symptoms and systemic complications. CD226, a co-stimulatory receptor implicated in the pathogenesis of multiple autoimmune diseases including system...