Different Cortical Thinning Patterns Depending on Their Prognosis in Individuals with Subjective Cognitive Decline

Subjective cognitive decline (SCD) may be the first stage corresponding to subtle cognitive changes in patients with Alzheimer's disease (AD) spectrum disorders. We evaluated the differences in cortical thinning patterns among patients with SCD who progressed to mild cognitive impairment or dem...

Full description

Saved in:
Bibliographic Details
Published inDementia and neurocognitive disorders Vol. 18; no. 4; pp. 113 - 121
Main Authors Lim, Eun Ye, Shim, Yong Soo, Hong, Yun Jeong, Ryu, Seon Young, Cho, A Hyun, Yang, Dong Won
Format Journal Article
LanguageEnglish
Published Korea (South) Korean Dementia Association 01.12.2019
대한치매학회
Subjects
Original
신경과학
Magnetic Resonance Imaging
Cognitive Decline
Alzheimer's Disease
Dementia
Online AccessGet full text
ISSN1738-1495
2384-0757
DOI10.12779/dnd.2019.18.4.113

Cover

Abstract Subjective cognitive decline (SCD) may be the first stage corresponding to subtle cognitive changes in patients with Alzheimer's disease (AD) spectrum disorders. We evaluated the differences in cortical thinning patterns among patients with SCD who progressed to mild cognitive impairment or dementia (pSCD), those who remained stable (sSCD), and healthy normal controls (NCs). We retrospectively recruited SCD subjects (14 pSCD and 21 sSCD cases) and 29 NCs. Structural 3-dimensional-T1-weighted magnetic resonance imaging was performed using a single 1.5 Tesla scanner. Freesurfer software was used to map cortical thickness for group comparisons. Compared with NC group, the sSCD group showed diffuse cortical atrophy associated with bilateral fronto-parieto-temporal area. The pSCD group showed further characteristic cortical atrophy in AD-vulnerable regions including the inferior parieto-temporal and middle temporal areas. Cortical thinning in the bilateral medial frontal areas was observed in patients with sSCD and involved the right inferior temporal and left precentral areas in those with pSCD. Our study showed that SCD subjects exhibit different cortical thinning patterns depending on their prognosis.
AbstractList Subjective cognitive decline (SCD) may be the first stage corresponding to subtle cognitive changes in patients with Alzheimer's disease (AD) spectrum disorders. We evaluated the differences in cortical thinning patterns among patients with SCD who progressed to mild cognitive impairment or dementia (pSCD), those who remained stable (sSCD), and healthy normal controls (NCs). We retrospectively recruited SCD subjects (14 pSCD and 21 sSCD cases) and 29 NCs. Structural 3-dimensional-T1-weighted magnetic resonance imaging was performed using a single 1.5 Tesla scanner. Freesurfer software was used to map cortical thickness for group comparisons. Compared with NC group, the sSCD group showed diffuse cortical atrophy associated with bilateral fronto-parieto-temporal area. The pSCD group showed further characteristic cortical atrophy in AD-vulnerable regions including the inferior parieto-temporal and middle temporal areas. Cortical thinning in the bilateral medial frontal areas was observed in patients with sSCD and involved the right inferior temporal and left precentral areas in those with pSCD. Our study showed that SCD subjects exhibit different cortical thinning patterns depending on their prognosis.
Background and Purpose: Subjective cognitive decline (SCD) may be the first stage corresponding to subtle cognitive changes in patients with Alzheimer's disease (AD) spectrum disorders. We evaluated the differences in cortical thinning patterns among patients with SCD who progressed to mild cognitive impairment or dementia (pSCD), those who remained stable (sSCD), and healthy normal controls (NCs). Methods: We retrospectively recruited SCD subjects (14 pSCD and 21 sSCD cases) and 29 NCs. Structural 3-dimensional-T1-weighted magnetic resonance imaging was performed using a single 1.5 Tesla scanner. Freesurfer software was used to map cortical thickness for group comparisons. Results: Compared with NC group, the sSCD group showed diffuse cortical atrophy associated with bilateral fronto-parieto-temporal area. The pSCD group showed further characteristic cortical atrophy in AD-vulnerable regions including the inferior parietotemporal and middle temporal areas. Cortical thinning in the bilateral medial frontal areas was observed in patients with sSCD and involved the right inferior temporal and left precentral areas in those with pSCD. Conclusions: Our study showed that SCD subjects exhibit different cortical thinning patterns depending on their prognosis. KCI Citation Count: 0
Author Hong, Yun Jeong
Ryu, Seon Young
Yang, Dong Won
Lim, Eun Ye
Shim, Yong Soo
Cho, A Hyun
AuthorAffiliation Department of Neurology, St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
AuthorAffiliation_xml – name: Department of Neurology, St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
Author_xml – sequence: 1
  givenname: Eun Ye
  orcidid: 0000-0002-4972-7070
  surname: Lim
  fullname: Lim, Eun Ye
  organization: Department of Neurology, St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
– sequence: 2
  givenname: Yong Soo
  orcidid: 0000-0001-5642-5401
  surname: Shim
  fullname: Shim, Yong Soo
  organization: Department of Neurology, St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
– sequence: 3
  givenname: Yun Jeong
  orcidid: 0000-0002-4996-4981
  surname: Hong
  fullname: Hong, Yun Jeong
  organization: Department of Neurology, St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
– sequence: 4
  givenname: Seon Young
  orcidid: 0000-0003-0527-2868
  surname: Ryu
  fullname: Ryu, Seon Young
  organization: Department of Neurology, St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
– sequence: 5
  givenname: A Hyun
  orcidid: 0000-0003-2506-0408
  surname: Cho
  fullname: Cho, A Hyun
  organization: Department of Neurology, St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
– sequence: 6
  givenname: Dong Won
  orcidid: 0000-0002-4733-7298
  surname: Yang
  fullname: Yang, Dong Won
  organization: Department of Neurology, St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
BackLink https://www.ncbi.nlm.nih.gov/pubmed/31942170$$D View this record in MEDLINE/PubMed
https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002547900$$DAccess content in National Research Foundation of Korea (NRF)
BookMark eNp9kUFvEzEQhS1URNPSP8AB7ZXDLh7bu7YvSFUCJVIlKghny-u1k2m33si7ScW_x0koAg74Mta8977DvAtyFofoCXkDtAImpX7fxa5iFHQFqhIVAH9BZowrUVJZyzMyA8lVCULX5-RqHO9pfoo1QOtX5JyDFgwknZG0wBB88nEq5kOa0Nm-WG0wRozr4s5Ok09xLBZ-62N3WA0xyx5TcZeGdRxGHAuMxTKLe-x2th-LJ5w2xbdde-_dhHufseuIx9_Cux6jf01ehmz0V7_mJfn-6eNq_rm8_XKznF_flo4p4KUNVuqGg-e8pTJQ6qhgrBZdC87VnZOqU7YOrea01Sq4UNecu9pK0VHmtOaX5N2JG1MwDw7NYPE414N5SOb662ppGtEA05C9H07e7a599J3L90i2N9uEjzb9OCb_ViJuMmdvGi2aBlQGvP0T8Dv5fOlsUCeDS8M4Jh-Mw8lOOBx42Bug5tiryb2aQ68GlBEm95qj7J_oM_0_oZ-p-aiI
CitedBy_id crossref_primary_10_1002_brb3_3408
crossref_primary_10_18632_aging_203467
crossref_primary_10_1186_s13195_021_00811_w
crossref_primary_10_1016_j_cmpb_2024_108281
crossref_primary_10_3389_fnagi_2024_1441359
crossref_primary_10_1186_s13195_022_01031_6
crossref_primary_10_1111_cns_14401
crossref_primary_10_1002_hbm_25216
Cites_doi 10.1016/j.jalz.2014.01.001
10.1523/JNEUROSCI.0391-14.2014
10.1007/s10548-016-0509-z
10.3233/JAD-140678
10.1111/j.1365-2796.2004.01388.x
10.1016/S0149-7634(00)00012-9
10.1016/S1474-4422(09)70139-5
10.1155/2015/296581
10.1016/j.neuroimage.2012.01.122
10.1016/j.dadm.2014.11.010
10.1002/nbm.1062
10.1016/j.neurobiolaging.2006.09.013
10.1006/nimg.1998.0395
10.1016/j.neurobiolaging.2014.03.034
10.1016/j.neuropsychologia.2012.08.011
10.1016/j.neuroimage.2012.09.058
10.1016/j.biopsych.2011.02.017
10.1089/neu.2015.4253
10.1001/jamaneurol.2013.1062
10.1056/NEJMoa054625
10.1001/archpsyc.63.5.530
10.1016/S1474-4422(09)70299-6
10.1212/WNL.0b013e31823efc6c
10.1016/j.nicl.2016.06.010
10.3233/JAD-142322
10.1212/WNL.0b013e31826c1a8d
10.1093/cercor/bhh200
10.12779/dnd.2019.18.3.77
10.1093/brain/awp105
10.1016/S1474-4422(07)70178-3
10.1212/WNL.0b013e3182166e96
10.1016/0022-3956(82)90033-4
10.1111/ane.12038
10.1002/ana.22333
10.1212/01.wnl.0000340981.97664.2f
10.1016/j.jalz.2013.05.1764
10.1016/j.jalz.2012.08.004
ContentType Journal Article
Copyright 2019 Korean Dementia Association.
2019 Korean Dementia Association 2019 Korean Dementia Association
Copyright_xml – notice: 2019 Korean Dementia Association.
– notice: 2019 Korean Dementia Association 2019 Korean Dementia Association
DBID AAYXX
CITATION
NPM
5PM
ACYCR
DOI 10.12779/dnd.2019.18.4.113
DatabaseName CrossRef
PubMed
PubMed Central (Full Participant titles)
Korean Citation Index
DatabaseTitle CrossRef
PubMed
DatabaseTitleList PubMed
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
EISSN 2384-0757
EndPage 121
ExternalDocumentID oai_kci_go_kr_ARTI_6461291
PMC6946618
31942170
10_12779_dnd_2019_18_4_113
Genre Journal Article
GroupedDBID 5-W
8JR
8XY
AAYXX
ADBBV
ALMA_UNASSIGNED_HOLDINGS
AOIJS
CITATION
EF.
HYE
OK1
PGMZT
RPM
NPM
5PM
ACYCR
ID FETCH-LOGICAL-c2813-afa79631e33b07f00c042254db1cc5dc78d8a5fb930b98fcf5533c5a74d02c993
ISSN 1738-1495
IngestDate Sun Mar 09 07:52:34 EDT 2025
Thu Aug 21 17:54:18 EDT 2025
Thu Jan 02 22:54:40 EST 2025
Thu Apr 24 23:09:06 EDT 2025
Tue Jul 01 03:28:20 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed false
IsScholarly true
Issue 4
Keywords Magnetic Resonance Imaging
Cognitive Decline
Alzheimer's Disease
Dementia
Language English
License 2019 Korean Dementia Association.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c2813-afa79631e33b07f00c042254db1cc5dc78d8a5fb930b98fcf5533c5a74d02c993
ORCID 0000-0001-5642-5401
0000-0003-2506-0408
0000-0002-4996-4981
0000-0002-4733-7298
0000-0002-4972-7070
0000-0003-0527-2868
OpenAccessLink https://pubmed.ncbi.nlm.nih.gov/PMC6946618
PMID 31942170
PageCount 9
ParticipantIDs nrf_kci_oai_kci_go_kr_ARTI_6461291
pubmedcentral_primary_oai_pubmedcentral_nih_gov_6946618
pubmed_primary_31942170
crossref_citationtrail_10_12779_dnd_2019_18_4_113
crossref_primary_10_12779_dnd_2019_18_4_113
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 20191201
PublicationDateYYYYMMDD 2019-12-01
PublicationDate_xml – month: 12
  year: 2019
  text: 20191201
  day: 1
PublicationDecade 2010
PublicationPlace Korea (South)
PublicationPlace_xml – name: Korea (South)
PublicationTitle Dementia and neurocognitive disorders
PublicationTitleAlternate Dement Neurocogn Disord
PublicationYear 2019
Publisher Korean Dementia Association
대한치매학회
Publisher_xml – name: Korean Dementia Association
– name: 대한치매학회
References Sousa (10.12779/dnd.2019.18.4.113_ref7) 2015; 2015
Hollands (10.12779/dnd.2019.18.4.113_ref8) 2015; 43
Lerch (10.12779/dnd.2019.18.4.113_ref11) 2005; 15
Scheef (10.12779/dnd.2019.18.4.113_ref34) 2012; 79
Kang (10.12779/dnd.2019.18.4.113_ref28) 2019; 18
Govindarajan (10.12779/dnd.2019.18.4.113_ref31) 2016; 33
Dickerson (10.12779/dnd.2019.18.4.113_ref14) 2011; 76
Shaw (10.12779/dnd.2019.18.4.113_ref30) 2016; 29
Querbes (10.12779/dnd.2019.18.4.113_ref18) 2009; 132
Amariglio (10.12779/dnd.2019.18.4.113_ref4) 2012; 50
Dickerson (10.12779/dnd.2019.18.4.113_ref13) 2012; 78
Doré (10.12779/dnd.2019.18.4.113_ref15) 2013; 70
Collie (10.12779/dnd.2019.18.4.113_ref35) 2000; 24
Fortea (10.12779/dnd.2019.18.4.113_ref27) 2011; 70
Schultz (10.12779/dnd.2019.18.4.113_ref24) 2015; 1
Visser (10.12779/dnd.2019.18.4.113_ref3) 2009; 8
Erickson (10.12779/dnd.2019.18.4.113_ref32) 2014; 35
Storsve (10.12779/dnd.2019.18.4.113_ref33) 2014; 34
van Harten (10.12779/dnd.2019.18.4.113_ref5) 2013; 9
Meiberth (10.12779/dnd.2019.18.4.113_ref25) 2015; 45
Balash (10.12779/dnd.2019.18.4.113_ref6) 2013; 127
Pettigrew (10.12779/dnd.2019.18.4.113_ref37) 2016; 12
Yesavage (10.12779/dnd.2019.18.4.113_ref19) 1982-1983; 17
Peter (10.12779/dnd.2019.18.4.113_ref23) 2014; 10
Panizzon (10.12779/dnd.2019.18.4.113_ref29) 2012; 60
Becker (10.12779/dnd.2019.18.4.113_ref26) 2011; 69
Small (10.12779/dnd.2019.18.4.113_ref9) 2006; 355
Lerch (10.12779/dnd.2019.18.4.113_ref12) 2008; 29
Jack (10.12779/dnd.2019.18.4.113_ref2) 2010; 9
Mueller (10.12779/dnd.2019.18.4.113_ref10) 2006; 19
Ownby (10.12779/dnd.2019.18.4.113_ref36) 2006; 63
Eskildsen (10.12779/dnd.2019.18.4.113_ref17) 2013; 65
Petersen (10.12779/dnd.2019.18.4.113_ref20) 2004; 256
Bakkour (10.12779/dnd.2019.18.4.113_ref16) 2009; 72
Dubois (10.12779/dnd.2019.18.4.113_ref21) 2007; 6
Dale (10.12779/dnd.2019.18.4.113_ref22) 1999; 9
Jessen (10.12779/dnd.2019.18.4.113_ref1) 2014; 10
References_xml – volume: 10
  start-page: 844
  year: 2014
  ident: 10.12779/dnd.2019.18.4.113_ref1
  publication-title: Alzheimers Dement
  doi: 10.1016/j.jalz.2014.01.001
– volume: 34
  start-page: 8488
  year: 2014
  ident: 10.12779/dnd.2019.18.4.113_ref33
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.0391-14.2014
– volume: 29
  start-page: 875
  year: 2016
  ident: 10.12779/dnd.2019.18.4.113_ref30
  publication-title: Brain Topogr
  doi: 10.1007/s10548-016-0509-z
– volume: 43
  start-page: 677
  year: 2015
  ident: 10.12779/dnd.2019.18.4.113_ref8
  publication-title: J Alzheimers Dis
  doi: 10.3233/JAD-140678
– volume: 256
  start-page: 183
  year: 2004
  ident: 10.12779/dnd.2019.18.4.113_ref20
  publication-title: J Intern Med
  doi: 10.1111/j.1365-2796.2004.01388.x
– volume: 24
  start-page: 365
  year: 2000
  ident: 10.12779/dnd.2019.18.4.113_ref35
  publication-title: Neurosci Biobehav Rev
  doi: 10.1016/S0149-7634(00)00012-9
– volume: 8
  start-page: 619
  year: 2009
  ident: 10.12779/dnd.2019.18.4.113_ref3
  publication-title: Lancet Neurol
  doi: 10.1016/S1474-4422(09)70139-5
– volume: 2015
  start-page: 296581
  year: 2015
  ident: 10.12779/dnd.2019.18.4.113_ref7
  publication-title: Curr Gerontol Geriatr Res
  doi: 10.1155/2015/296581
– volume: 60
  start-page: 1686
  year: 2012
  ident: 10.12779/dnd.2019.18.4.113_ref29
  publication-title: Neuroimage
  doi: 10.1016/j.neuroimage.2012.01.122
– volume: 1
  start-page: 33
  year: 2015
  ident: 10.12779/dnd.2019.18.4.113_ref24
  publication-title: Alzheimers Dement (Amst)
  doi: 10.1016/j.dadm.2014.11.010
– volume: 19
  start-page: 655
  year: 2006
  ident: 10.12779/dnd.2019.18.4.113_ref10
  publication-title: NMR Biomed
  doi: 10.1002/nbm.1062
– volume: 29
  start-page: 23
  year: 2008
  ident: 10.12779/dnd.2019.18.4.113_ref12
  publication-title: Neurobiol Aging
  doi: 10.1016/j.neurobiolaging.2006.09.013
– volume: 9
  start-page: 179
  year: 1999
  ident: 10.12779/dnd.2019.18.4.113_ref22
  publication-title: Neuroimage
  doi: 10.1006/nimg.1998.0395
– volume: 35
  start-page: S20
  issue: Suppl 2
  year: 2014
  ident: 10.12779/dnd.2019.18.4.113_ref32
  publication-title: Neurobiol Aging
  doi: 10.1016/j.neurobiolaging.2014.03.034
– volume: 50
  start-page: 2880
  year: 2012
  ident: 10.12779/dnd.2019.18.4.113_ref4
  publication-title: Neuropsychologia
  doi: 10.1016/j.neuropsychologia.2012.08.011
– volume: 65
  start-page: 511
  year: 2013
  ident: 10.12779/dnd.2019.18.4.113_ref17
  publication-title: Neuroimage
  doi: 10.1016/j.neuroimage.2012.09.058
– volume: 70
  start-page: 183
  year: 2011
  ident: 10.12779/dnd.2019.18.4.113_ref27
  publication-title: Biol Psychiatry
  doi: 10.1016/j.biopsych.2011.02.017
– volume: 33
  start-page: 1809
  year: 2016
  ident: 10.12779/dnd.2019.18.4.113_ref31
  publication-title: J Neurotrauma
  doi: 10.1089/neu.2015.4253
– volume: 70
  start-page: 903
  year: 2013
  ident: 10.12779/dnd.2019.18.4.113_ref15
  publication-title: JAMA Neurol
  doi: 10.1001/jamaneurol.2013.1062
– volume: 355
  start-page: 2652
  year: 2006
  ident: 10.12779/dnd.2019.18.4.113_ref9
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa054625
– volume: 63
  start-page: 530
  year: 2006
  ident: 10.12779/dnd.2019.18.4.113_ref36
  publication-title: Arch Gen Psychiatry
  doi: 10.1001/archpsyc.63.5.530
– volume: 9
  start-page: 119
  year: 2010
  ident: 10.12779/dnd.2019.18.4.113_ref2
  publication-title: Lancet Neurol
  doi: 10.1016/S1474-4422(09)70299-6
– volume: 78
  start-page: 84
  year: 2012
  ident: 10.12779/dnd.2019.18.4.113_ref13
  publication-title: Neurology
  doi: 10.1212/WNL.0b013e31823efc6c
– volume: 12
  start-page: 116
  year: 2016
  ident: 10.12779/dnd.2019.18.4.113_ref37
  publication-title: Neuroimage Clin
  doi: 10.1016/j.nicl.2016.06.010
– volume: 45
  start-page: 139
  year: 2015
  ident: 10.12779/dnd.2019.18.4.113_ref25
  publication-title: J Alzheimers Dis
  doi: 10.3233/JAD-142322
– volume: 79
  start-page: 1332
  year: 2012
  ident: 10.12779/dnd.2019.18.4.113_ref34
  publication-title: Neurology
  doi: 10.1212/WNL.0b013e31826c1a8d
– volume: 15
  start-page: 995
  year: 2005
  ident: 10.12779/dnd.2019.18.4.113_ref11
  publication-title: Cereb Cortex
  doi: 10.1093/cercor/bhh200
– volume: 18
  start-page: 77
  year: 2019
  ident: 10.12779/dnd.2019.18.4.113_ref28
  publication-title: Dement Neurocogn Disord
  doi: 10.12779/dnd.2019.18.3.77
– volume: 132
  start-page: 2036
  year: 2009
  ident: 10.12779/dnd.2019.18.4.113_ref18
  publication-title: Brain
  doi: 10.1093/brain/awp105
– volume: 6
  start-page: 734
  year: 2007
  ident: 10.12779/dnd.2019.18.4.113_ref21
  publication-title: Lancet Neurol
  doi: 10.1016/S1474-4422(07)70178-3
– volume: 76
  start-page: 1395
  year: 2011
  ident: 10.12779/dnd.2019.18.4.113_ref14
  publication-title: Neurology
  doi: 10.1212/WNL.0b013e3182166e96
– volume: 17
  start-page: 37
  year: 1982-1983
  ident: 10.12779/dnd.2019.18.4.113_ref19
  publication-title: J Psychiatr Res
  doi: 10.1016/0022-3956(82)90033-4
– volume: 127
  start-page: 344
  year: 2013
  ident: 10.12779/dnd.2019.18.4.113_ref6
  publication-title: Acta Neurol Scand
  doi: 10.1111/ane.12038
– volume: 69
  start-page: 1032
  year: 2011
  ident: 10.12779/dnd.2019.18.4.113_ref26
  publication-title: Ann Neurol
  doi: 10.1002/ana.22333
– volume: 72
  start-page: 1048
  year: 2009
  ident: 10.12779/dnd.2019.18.4.113_ref16
  publication-title: Neurology
  doi: 10.1212/01.wnl.0000340981.97664.2f
– volume: 10
  start-page: 99
  year: 2014
  ident: 10.12779/dnd.2019.18.4.113_ref23
  publication-title: Alzheimers Dement
  doi: 10.1016/j.jalz.2013.05.1764
– volume: 9
  start-page: 481
  year: 2013
  ident: 10.12779/dnd.2019.18.4.113_ref5
  publication-title: Alzheimers Dement
  doi: 10.1016/j.jalz.2012.08.004
SSID ssj0000826105
Score 2.088287
Snippet Subjective cognitive decline (SCD) may be the first stage corresponding to subtle cognitive changes in patients with Alzheimer's disease (AD) spectrum...
Background and Purpose: Subjective cognitive decline (SCD) may be the first stage corresponding to subtle cognitive changes in patients with Alzheimer's...
SourceID nrf
pubmedcentral
pubmed
crossref
SourceType Open Website
Open Access Repository
Index Database
Enrichment Source
StartPage 113
SubjectTerms Original
신경과학
Title Different Cortical Thinning Patterns Depending on Their Prognosis in Individuals with Subjective Cognitive Decline
URI https://www.ncbi.nlm.nih.gov/pubmed/31942170
https://pubmed.ncbi.nlm.nih.gov/PMC6946618
https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002547900
Volume 18
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
ispartofPNX Dementia and Neurocognitive Disorders(대한치매학회지), 2019, 18(4), 56, pp.113-121
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELa25cIFgXgtj8pC5LTKEm-ctX1Md4tapFY9tFI5RbGTQCjKorB74XfzA5ix82wBFS6R5YwnieeLPWPNg5C3XCsRao4S0KnPdWB8jadN0SLnqQT7Qy4xGvn0bHl8yT9cRVeTyc-B19Juq-fmx2_jSv5HqtAHcsUo2X-QbMcUOqAN8oUrSBiud5LxuqlusoXfunaH0liH0x51nNvEmdV3WFGwzK11bq7QwaKsMToA_etK6wt70oVkNZFusJZ8ccsgsO2dizCGcuQ3tLYniy6oa2bzYva-SFmT1LPX2HfV7GOO8VRtj3e08uShF6-woWIvVrZHekr2JGtPKU-uLcnKizk24sBzFTMdCbCIYIwdzPEm0krPlWhpDzSYuuEcguPkCv088BkRcodxh8pyApbCPszdUrYRA_1gCRewhKPd53Y42wd6CfdBORKDpZq5GNhm12cuTvvWhrIQAhOyZhVmlWVqzuScz7uhw-zdN3bVUf7ua1MmnzbJdZ2AlXKSLDnolZhy4R6wt84F7RmT1R_A4nO-t92nNNFe-DLvbr3KSKPaq-pioEyNHX0HmtPFQ_KgMXlo7PD7iEzy6jGpO-zSFru0xS5tsUs77NJNRS12aYddWlZ0gF2K2KU9dmmHXdpg9wm5fH90sTr2m_ofvllIFvppkQrYH1gehjoQRRAYTFgX8UwzY6LMCJnJNCq0CgOtZGGKCGwXE6WCZ8HCgOL9lOxXmyp_TihMU5rrlKNHN18wrjlXYFgI4K2DosimhLVzmJgmOT7WaPmaoJGM857AvCc47wmTCQfDOZySWTfmm0sN81fqNyAai4Q_I2JKnjmBdQxhh4T3FcGUiJEoOwJkNr5TlZ9tmvgllo5g8sVdHvyS3O9_xVdkf1vv8tegbW_1Adk7Oz89sBD9BREgySo
linkProvider National Library of Medicine
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Different+Cortical+Thinning+Patterns+Depending+on+Their+Prognosis+in+Individuals+with+Subjective+Cognitive+Decline&rft.jtitle=Dementia+and+neurocognitive+disorders&rft.au=Eun+Ye+Lim&rft.au=%EC%8B%AC%EC%9A%A9%EC%88%98&rft.au=%ED%99%8D%EC%9C%A4%EC%A0%95&rft.au=%EB%A5%98%EC%84%A0%EC%98%81&rft.date=2019-12-01&rft.pub=%EB%8C%80%ED%95%9C%EC%B9%98%EB%A7%A4%ED%95%99%ED%9A%8C&rft.issn=1738-1495&rft.eissn=2384-0757&rft.spage=113&rft.epage=121&rft_id=info:doi/10.12779%2Fdnd.2019.18.4.113&rft.externalDBID=n%2Fa&rft.externalDocID=oai_kci_go_kr_ARTI_6461291
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1738-1495&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1738-1495&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1738-1495&client=summon