Effect of acupuncture and moxibustion on the immune function of patients with malignant tumors: a systematic review and meta-analysis
Acupuncture and moxibustion have been shown to be safe and effective methods for bidirectional immunomodulatory function. Clinical practice and many studies have shown that acupuncture and moxibustion have a certain clinical effect on immune promotion in patients with malignant tumors. Eight electro...
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| Published in | Frontiers in immunology Vol. 16; p. 1583522 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
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2025
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| Abstract | Acupuncture and moxibustion have been shown to be safe and effective methods for bidirectional immunomodulatory function. Clinical practice and many studies have shown that acupuncture and moxibustion have a certain clinical effect on immune promotion in patients with malignant tumors.
Eight electronic databases were searched systematically for articles published through December 31, 2024. Study Selection Randomized controlled trial studies (RCTs) that reported The number of T lymphocytes cells in patients with malignant tumors who received acupuncture and/or moxibustionon treatment were included. For continuous variables, effect estimates were calculated as mean difference (MD); and for dichotomous variables, the risk ratio (RR) was calculated. A funnel plot was used to analyze potential publication bias.
33 studies involving 2610 participants were included. Patients who received acupuncture and/or moxibustion treatment had higher CD3
, CD4
, CD4
/CD8
and natural killer (NK) cell levels, but lower CD8
levels. At the same time, the anti-tumor treatment effect was better than that of the control group.
Evidence from this meta-analysis, acupuncture and moxibustion can enhance the immune function and improve the prognosis of malignant tumor patients. Further studies are recommended to support and confirm these findings.
https://www.crd.york.ac.uk/prospero/, identifier CRD42023465759. |
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| AbstractList | BackgroundAcupuncture and moxibustion have been shown to be safe and effective methods for bidirectional immunomodulatory function. Clinical practice and many studies have shown that acupuncture and moxibustion have a certain clinical effect on immune promotion in patients with malignant tumors.MethodsEight electronic databases were searched systematically for articles published through December 31, 2024. Study Selection Randomized controlled trial studies (RCTs) that reported The number of T lymphocytes cells in patients with malignant tumors who received acupuncture and/or moxibustionon treatment were included. For continuous variables, effect estimates were calculated as mean difference (MD); and for dichotomous variables, the risk ratio (RR) was calculated. A funnel plot was used to analyze potential publication bias.Results33 studies involving 2610 participants were included. Patients who received acupuncture and/or moxibustion treatment had higher CD3+, CD4+, CD4+/CD8+ and natural killer (NK) cell levels, but lower CD8+ levels. At the same time, the anti-tumor treatment effect was better than that of the control group.ConclusionsEvidence from this meta-analysis, acupuncture and moxibustion can enhance the immune function and improve the prognosis of malignant tumor patients. Further studies are recommended to support and confirm these findings.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42023465759. Acupuncture and moxibustion have been shown to be safe and effective methods for bidirectional immunomodulatory function. Clinical practice and many studies have shown that acupuncture and moxibustion have a certain clinical effect on immune promotion in patients with malignant tumors.BackgroundAcupuncture and moxibustion have been shown to be safe and effective methods for bidirectional immunomodulatory function. Clinical practice and many studies have shown that acupuncture and moxibustion have a certain clinical effect on immune promotion in patients with malignant tumors.Eight electronic databases were searched systematically for articles published through December 31, 2024. Study Selection Randomized controlled trial studies (RCTs) that reported The number of T lymphocytes cells in patients with malignant tumors who received acupuncture and/or moxibustionon treatment were included. For continuous variables, effect estimates were calculated as mean difference (MD); and for dichotomous variables, the risk ratio (RR) was calculated. A funnel plot was used to analyze potential publication bias.MethodsEight electronic databases were searched systematically for articles published through December 31, 2024. Study Selection Randomized controlled trial studies (RCTs) that reported The number of T lymphocytes cells in patients with malignant tumors who received acupuncture and/or moxibustionon treatment were included. For continuous variables, effect estimates were calculated as mean difference (MD); and for dichotomous variables, the risk ratio (RR) was calculated. A funnel plot was used to analyze potential publication bias.33 studies involving 2610 participants were included. Patients who received acupuncture and/or moxibustion treatment had higher CD3+, CD4+, CD4+/CD8+ and natural killer (NK) cell levels, but lower CD8+ levels. At the same time, the anti-tumor treatment effect was better than that of the control group.Results33 studies involving 2610 participants were included. Patients who received acupuncture and/or moxibustion treatment had higher CD3+, CD4+, CD4+/CD8+ and natural killer (NK) cell levels, but lower CD8+ levels. At the same time, the anti-tumor treatment effect was better than that of the control group.Evidence from this meta-analysis, acupuncture and moxibustion can enhance the immune function and improve the prognosis of malignant tumor patients. Further studies are recommended to support and confirm these findings.ConclusionsEvidence from this meta-analysis, acupuncture and moxibustion can enhance the immune function and improve the prognosis of malignant tumor patients. Further studies are recommended to support and confirm these findings.https://www.crd.york.ac.uk/prospero/, identifier CRD42023465759.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42023465759. Acupuncture and moxibustion have been shown to be safe and effective methods for bidirectional immunomodulatory function. Clinical practice and many studies have shown that acupuncture and moxibustion have a certain clinical effect on immune promotion in patients with malignant tumors. Eight electronic databases were searched systematically for articles published through December 31, 2024. Study Selection Randomized controlled trial studies (RCTs) that reported The number of T lymphocytes cells in patients with malignant tumors who received acupuncture and/or moxibustionon treatment were included. For continuous variables, effect estimates were calculated as mean difference (MD); and for dichotomous variables, the risk ratio (RR) was calculated. A funnel plot was used to analyze potential publication bias. 33 studies involving 2610 participants were included. Patients who received acupuncture and/or moxibustion treatment had higher CD3 , CD4 , CD4 /CD8 and natural killer (NK) cell levels, but lower CD8 levels. At the same time, the anti-tumor treatment effect was better than that of the control group. Evidence from this meta-analysis, acupuncture and moxibustion can enhance the immune function and improve the prognosis of malignant tumor patients. Further studies are recommended to support and confirm these findings. https://www.crd.york.ac.uk/prospero/, identifier CRD42023465759. |
| Author | Fang, Liyuan Wang, Runxi Sui, Bailu Fang, Yuhang Zhang, Ying Xie, Yi Wang, Yan |
| Author_xml | – sequence: 1 givenname: Yan surname: Wang fullname: Wang, Yan – sequence: 2 givenname: Bailu surname: Sui fullname: Sui, Bailu – sequence: 3 givenname: Ying surname: Zhang fullname: Zhang, Ying – sequence: 4 givenname: Liyuan surname: Fang fullname: Fang, Liyuan – sequence: 5 givenname: Yi surname: Xie fullname: Xie, Yi – sequence: 6 givenname: Yuhang surname: Fang fullname: Fang, Yuhang – sequence: 7 givenname: Runxi surname: Wang fullname: Wang, Runxi |
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| Keywords | malignant tumors meta-analysis acupuncture T lymphocyte cells moxibustion |
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| SubjectTerms | acupuncture Acupuncture Therapy - methods Humans malignant tumors meta-analysis moxibustion Moxibustion - methods Neoplasms - immunology Neoplasms - therapy Randomized Controlled Trials as Topic T lymphocyte cells Treatment Outcome |
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| Title | Effect of acupuncture and moxibustion on the immune function of patients with malignant tumors: a systematic review and meta-analysis |
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