Association of Dietary Polyphenol Intakes with Metabolic Syndrome and its Components: Tehran Lipid and Glucose Study

• Published in: Archives of Iranian medicine Vol. 27; no. 7; pp. 379 - 384
• Main Authors: Esfandiar, Zohre, Hosseini-Esfahani, Firoozeh, Mirmiran, Parvin, Hasheminia, Mitra, Azizi, Fereidoun
• Format: Journal Article
• Language: English
• Published: Iran Academy of Medical Sciences of I.R. Iran 01.07.2024
• Subjects: Adult; Blood Glucose - analysis; Diet; Female; Humans; Incidence; Iran - epidemiology; Male; Metabolic syndrome; Metabolic Syndrome - epidemiology; Middle Aged; Original; Polyphenols; Polyphenols - administration & dosage; Proportional Hazards Models; Prospective Studies; Risk Factors; Iran; Flavonoids; Polyphenol; Stilbenes; Diet; Lignans; Metabolic syndrome; Phenolic acids
• ISSN: 1029-2977; 1735-3947
• DOI: 10.34172/aim.28512

Background: This study was conducted to assess the prospective association between dietary polyphenols intakes and risk of metabolic syndrome (MetS) and its components. Methods: Participants in this study (n=4559) were selected from among the adults of the Tehran Lipid and Glucose Study (TLGS) with an average follow-up of 5.9+2.5 years. Biochemical and anthropometric variables were measured at baseline and follow-up examinations. A reliable and valid semi-quantitative food frequency questionnaire was used to evaluate dietary intakes. The incidence of MetS and its components in relation to polyphenols and its subclasses (phenolic acids, flavonoids, lignans, and stilbenes) was evaluated using multivariable Cox proportional hazard regression models. Results: Of the 4559 subjects who enrolled in the present study, 1765 were male aged 38.6+14.2 y and 2794 were female aged 35.9+11.7 y. The hazard ratios of MetS were 25% lower in Q2 (HR, 95% CI: 0.75, 0.64‒0.88), 22% lower in Q3 (HR, 95% CI: 0.78, 0.65‒0.94) and 24% lower in Q4 (HR, 95% CI: 0.76, 0.61‒0.95) in comparison to Q1, whereas the results for subclasses of polyphenol were non-significant. The risk of high blood pressure (BP) reduced from quartiles 1 to 4 for phenolic acid (HR: 1.00, 0.88, 0.79, 0.80, Ptrend=0.03). The risk of low high-density lipoprotein cholesterol (HDL-C) increased across quartiles of phenolic acid (HR: 1.00, 1.22, 1.07, 1.30, Ptrend=0.02). Conclusion: This study highlights the potential protective role of total dietary polyphenols in the prevention of MetS. These findings could be the starting point of upcoming trials to illuminate the optimal level of polyphenols deriving from the intake of polyphenol-rich diets to prevent MetS.