Multi-omics analysis of potential metabolic networks linking peripheral metabolic changes to inflammatory retinal conditions in STZ-induced early diabetic retinopathy

• Published in: Biochemistry and biophysics reports Vol. 43; p. 102182
• Main Authors: Zhang, Xiaonan, Liu, Yan, Xia, Mengxue, Yang, Manwen, Wu, Yingjie, Zhang, Fang
• Format: Journal Article
• Language: English
• Published: Elsevier 01.09.2025
• Subjects: Diabetic retinopathy; GWAS; Metabolomics; Retina; Serum; Transcriptomics
• ISSN: 2405-5808; 2405-5808
• DOI: 10.1016/j.bbrep.2025.102182

Background: Diabetic retinopathy (DR), a leading cause of blindness among working-age adults, lacks targeted therapies besides glucose management. Early retinal lesions are linked to serum metabolites, but the underlying peripheral regulatory networks is unclear. Methods: We first established a stre...