Oxidation of plasma low-density lipoproteins from coronary patients with various forms of hypercholesterolemia

• Published in: Bulletin of experimental biology and medicine Vol. 136; no. 1; pp. 42 - 45
• Main Authors: Lankin, V Z, Konovalova, G G, Tikhaze, A K, Nezhdanova, I B, Olfer'ev, A M, Kukharchuk, V V
• Format: Journal Article
• Language: English
• Published: United States Springer Nature B.V 01.07.2003
• Subjects: Adult; Antioxidants - pharmacology; Cholesterol - metabolism; Female; Free Radicals; Heart Diseases - blood; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology; Hypercholesterolemia - pathology; Kinetics; Lipid Peroxides - metabolism; Lipoproteins, LDL - blood; Male; Middle Aged; Models, Chemical; Oxygen - metabolism; Time Factors; Ubiquinone - analogs & derivatives; Ubiquinone - antagonists & inhibitors; Ubiquinone - biosynthesis

The duration of lag-phase of copper-induced free-radical oxidation of atherogenic LDL isolated from the plasma of coronary patients without hypercholesterolemia virtually does not differ from that of normal human LDL. On the other hand, lag-phase of plasma LDL oxidation was minimal in coronary patie...