BM 12.434, a novel compound with vasodilating and beta-adrenoceptor-blocking activities

• Published in: Clinical science (1979) Vol. 61 Suppl 7; pp. 477s - 479s
• Main Authors: von Möllendorff, E, Huschka, C, Schröter, E, Abshagen, U
• Format: Journal Article
• Language: English
• Published: England 01.12.1981
• Subjects: Adrenergic beta-Antagonists - pharmacology; Adult; Double-Blind Method; Hemodynamics - drug effects; Humans; Indoles - pharmacology; Male; Random Allocation; Vasodilator Agents - pharmacology

1. BM 12.434 was compared with a known beta-adrenoceptor-blocking agent, metipranolol, and a combination of metipranolol and isosorbide-5-mononitrate in healthy volunteers. BM 12.434 and metipranolol were given in equi-effective beta-adrenoceptor-blocking doses (reduction of exercise-increased pulse...