Divergent C-terminal motifs in Gα12 and Gα13 provide distinct mechanisms of effector binding and SRF activation

• Published in: Cellular signalling Vol. 72; p. 109653
• Main Authors: Stecky, Rebecca C., Quick, Courtney R., Fleming, Todd L., Mull, Makenzy L., Vinson, Vanessa K., Whitley, Megan S., Dover, E. Nicole, Meigs, Thomas E.
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.08.2020
• Subjects: Gα12; Gα13; Heterotrimeric G protein; RhoGEF; Serum response element; Serum response factor; PBS; Gα13; Gα12; SRF; SRE; GST; LARG; MRTFA; Serum response element; HEK; Hsp90; Heterotrimeric G protein; DMEM; RhoGEF; RH; Serum response factor; G protein

The G12/13 subfamily of heterotrimeric guanine nucleotide binding proteins comprises the α subunits Gα12 and Gα13, which transduce signals for cell growth, cytoskeletal rearrangements, and oncogenic transformation. In an increasing range of cancers, overexpressed Gα12 or Gα13 are implicated in aberr...