LncRNA TP73-AS1/miR-539/MMP-8 axis modulates M2 macrophage polarization in hepatocellular carcinoma via TGF-β1 signaling

• Published in: Cellular signalling Vol. 75; p. 109738
• Main Authors: Chen, Jun, Huang, Ze-Bing, Liao, Cheng-Jin, Hu, Xing-Wang, Li, Sha-Ling, Qi, Min, Fan, Xue-Gong, Huang, Yan
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.11.2020
• Subjects: lncRNA TP73-AS1; M2 macrophage polarization; miR-539; MMP-8; TGF-β1; lncRNA TP73-AS1; lncRNA; qRT-PCR; miR-539; HCC; ncRNAs; PVDF; ECM; M2 macrophage polarization; M2 macrophages; MMP; DMEM; SDS-PAGE; SD; TAMs; ANOVA; TGF-β1; TGF-β; TP73-AS1; MMP-8; ELISA

Our study aimed to study the role of lncRNA TP73-AS1/miR-539/MMP-8 axis in modulating M2 macrophage polarization in hepatocellular carcinoma (HCC). The gene expression levels of TP73-AS1, miR-539 and MMP-8 were modified by transfection with the overexpression or knockdown vectors. The patient surviv...