Unraveling architectural RNAs: Structural and functional blueprints of membraneless organelles and strategies for genome-scale identification

• Published in: Biochimica et biophysica acta. General subjects Vol. 1869; no. 8; p. 130815
• Main Authors: Fujiwara, Naoko, Ueno, Tsuyoshi, Yamazaki, Tomohiro, Hirose, Tetsuro
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.07.2025
• Subjects: Animals; Architectural RNA; Genome; HSATIII; Humans; Membraneless organelle; NEAT1_2; Nuclear stress bodies; Nucleic Acid Conformation; Organelles - genetics; Organelles - metabolism; Paraspekle; RNA, Long Noncoding - chemistry; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; Semi-extractability; Architectural RNA; Semi-extractability; NEAT1_2; HSATIII; Nuclear stress bodies; Paraspekle; Membraneless organelle

Architectural RNAs (arcRNAs) are long noncoding RNAs that serve as structural scaffolds for membraneless organelles (MLOs), facilitating cellular organization and dynamic responses to stimuli. Acting as blueprints for MLO assembly, arcRNAs recruit specific proteins and nucleic acids to establish and...